Skip to main content
OpenTrials
Completed

NCT Number: NCT02791984

Respiratory Variability in Aortic Blood Velocity Measured by Suprasternal View as an Indicator of Fluid Responsiveness

Respiratory changes in aortic blood velocity have been described as an indicator of fluid responsiveness when measured in the left ventricular outflow tract by trans esophageal echography. A threshold value of 12% allowed discrimination between responders and nonresponders with a sensitivity of 100% and a specificity of 89%. The suprasternal window is already used to measure cardiac output. The primary endpoint of this study is to determine the predictive value of the respiratory variability in aortic blood velocity measured by suprasternal view (∆VpicSS) as an indicator of fluid responsiveness. The secondary endpoint is to compare maximum velocity and velocity time integral measured by suprasternal and transthoracic view.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cardiovascular System

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hopital de la Croix-Rousse, Hospices Civils de Lyon

Lyon, 69002, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age more than 18 years
  • American Society of Anesthesiologists (ASA) score 1 or 2
  • General Anesthesia with mechanical ventilation
  • General Surgery

Exclusion criteria

  • Arrhythmia
  • Spontaneous breathing activity
  • Significant valvular disease

Treatment and study plan

Fluid challenge with 250 ml of Ringer Lactate

Device

Fluid challenge with 250 ml of Ringer Lactate over less than 2 minutes, intra-venous, help by a syringe of 50 ml.

Measure of peak velocity before and after the fluid challenge

Primary outcomes

  1. Percentage of cardiac flow variability

    Time frame: At day 1(before surgery)

    Percentage of cardiac flow variability between the 2 echographic measures. Echographic measures will be realized a first time before fluid challenge by suprasternal view and a second time after the fluid challenge by suprasternal view.

Secondary outcomes

  1. Comparison of percentage of cardiac flow variability between transthoracic and suprasternal views

    Time frame: At day 1(before surgery)

    Echographic measures will be realized a first time before fluid challenge by transthoracic and by suprasternal view and a second time after the fluid challenge by transthoracic and by suprasternal view.

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: SUPRA-PAM

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jun 7, 2016
Registry last updated
Jun 7, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.