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OpenTrials
Completed

NCT Number: NCT03514823

Respiratory Muscle Contribution to Blood Pressure During Exercise

The investigators seek to understand how reflexes from the breathing muscles influence blood pressure during exercise. Furthermore, the investigators are determining if increasing breathing muscle strength (via inspiratory muscle training) influences the respiratory muscle contribution to blood pressure during exercise.

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Key information

Conditions

Respiratory Muscle Blood Pressure Exercise Capacity Sympathetic Nerve Activity

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic

Rochester, Minnesota, 55901, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Healthy participants with no history of cardiovascular, pulmonary, neurologic, orthopedic or other neuromuscular diseases.

Treatment and study plan

Inspiratory muscle training (IMT)

Other

Inspiratory muscle training (IMT) are breathing exercises used to increase strength and endurance of the respiratory muscles.

No Inspiratory Muscle Training (IMT)

Other

No inspiratory muscle training.

Primary outcomes

  1. VO2 max test

    Time frame: Through study completion, an average of one year.

    Using a MedGraphics metabolic cart, the investigators will measure the maximum amount of oxygen that an individual can utilize during exercise. During this test the subject will be asked to exercise to his/her max capacity on a recumbent bicycle while breathing through a mouth piece that is hooked into the MedGraphics computer software.

  2. Blood Pressure

    Time frame: Through study completion, an average of one year.

    Blood pressure will be taken every few minutes during exercise testing using a standard blood pressure cuff to monitor changes in blood pressure.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Official study title

Respiratory Muscle Contribution to Blood Pressure During Exercise in Healthy Humans

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
May 2, 2018
Registry last updated
Jul 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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