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OpenTrials
Completed

NCT Number: NCT01992835

Resolution of Allergic Inflammation

After an allergen challenge, the allergic inflammatory response disappears spontaneously. The initiation of the resolution of the inflammatory response is now recognized as a dynamic process, involving active biochemical programs that enable inflamed tissues to return to homeostasis. Recent data established key roles of different specific lipid mediators in the endogenous counter-regulation of inflammation and activation of resolution. Only little is known about kinetics of these specialized pro-resolving lipid mediators during acute allergic inflammation. Therefore, the primary propose of our study is to characterize the temporal evolution of cellular inflammation and specific lipid mediators after allergen challenge.

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Key information

Conditions

Grass Pollen Allergic Rhinitis

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpitaux Universitaires

Strasbourg, 67091, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Eligibility criteria:

Inclusion criteria

  • Allergic rhinitis during the grass pollen season with or without asthma, with at least one of the following symptoms: nasal congestion, itching, rhinorrhea, sneezing
  • Grass pollen sensitization determined by a positive skin prick test and / or presence of specific IgEs to a grass pollen allergen extract

Exclusion criteria

  • Smoker
  • Specific immunotherapy with grass allergens or other respiratory allergen for inclusion.
  • Current exhibition to another clinically relevant respiratory allergen

Treatment and study plan

Grass pollen allergen extract

Other

Each subject will be challenged with a grass pollen allergen extract and with placebo.

Placebo

Other

Primary outcomes

  1. Clinical nasal score and measurement of mediators in biological fluids

    Time frame: Measurement of mediators in biological fluids during 72 h after nasal allergen challenge

  2. Clinical nasal score and measurement of mediators in biological fluids.

    Time frame: Measurement and indentification of specific lipid mediators during nasal allergen challenge

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Resolution of Allergic Inflammation: Identification and Kinetics of Specific Lipid Mediators During Nasal Allergen Challenge

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Nov 25, 2013
Registry last updated
Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.