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Completed

NCT Number: NCT01083017

Resistant Arterial Hypertension Cohort Study

The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.

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Key information

Conditions

Hypertension Cardiovascular Diseases Essential Hypertension Resistant Hypertension Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Geneva University Hospitals, Geneva, Switzerland

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • informed consent
  • resistant hypertension at the moment of inclusion
  • 18 years or more, both sexes are included
  • women at reproductive age: consenting to use oral contraception

Exclusion criteria

  • patients mentally impaired or unable to give informed consent
  • patients speaking only a foreign language other than French, German, or English
  • patients living far away, making the study visits not practical

Treatment and study plan

Chlorthalidone

Drug

chlorthalidone 25mg/d vs. chlorthalidone 50mg/d

motivational intervention for non-compliant individuals

Behavioral

motivational interview(s) vs. repeated calls vs. no particular intervention

standardized anti-hypertensive treatment

Drug

olmesartan, amlodipine, chlorthalidone, +- spironolactone

Primary outcomes

  1. blood pressure control

    Time frame: at 12 weeks after initiation of standard treatment

Secondary outcomes

  1. cardiovascular morbidity and mortality

    Time frame: 5 years

    additional secondary: BP control at yearly follow-up

Sponsors and collaborators

Lead sponsor

University Hospital, Geneva

Other

Registry information

Official study title

Interventional Prospective Cohort Study, Multi-center With Nested Case-control Studies (Family-based and Non-family Based) on Individuals With Resistant Arterial Hypertension.

Acronym: RAHyCo

Important dates

Study start
2011
Primary completion
2017
Study completion
2017
First posted
Mar 9, 2010
Registry last updated
Oct 30, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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