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OpenTrials
Completed

NCT Number: NCT05863039

Resistance Training With Blood Flow Restriction

Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Findings of this project will provide important information regarding a promising intervention to potentiate muscle performance.

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Key information

Conditions

Healthy

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Oklahoma

Norman, Oklahoma, 73071, United States

About this study

The purpose of this study is to determine alterations in motor unit behavior of the tibialis anterior muscles after a resistance exercise program associated with blood flow restriction. Our working hypothesis is that blood flow restriction to working muscles will induce greater changes in muscle activation, lean mass and muscle size compared with a training at same intensity without blood flow restriction.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

  • presence of neurological diseases,
  • presence of metal implants or joint replacement
  • any restriction to perform physical activity
  • pregnancy

Treatment and study plan

Blood Flow Restriction

Other

Strength training of the lower leg muscles using blood flow restriction

Regular training type 1

Other

Strength training of the lower leg muscles using high loads

Regular training type 2

Other

Strength training of the lower leg muscles using low loads

Primary outcomes

  1. Force

    Time frame: 10 sessions (up to 6 weeks)

    Force of the lower leg muscles using a custom made ergometer

Secondary outcomes

  1. Body composition

    Time frame: Start and end of the protocol

    dual x-ray absorptiometry (DEXA) will be used to assess body composition

Sponsors and collaborators

Lead sponsor

University of Oklahoma

Other

Registry information

Official study title

Resistance Training With Blood Flow Restriction for the Lower Extremity Muscles

Important dates

Study start
2022
Primary completion
2025
Study completion
2026
First posted
May 17, 2023
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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