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Completed

NCT Number: NCT05482750

Resistance Training in the Fasted State

It is well evidenced in the literature that fasting aerobic exercise generates a series of metabolic differences when compared to exercise performed in the fed state, including the use of fats predominantly as an energy source. Consequently, increases in adaptations to aerobic training, related to health and physical performance, are observed when sessions are performed in the fasted state. In relation to resistance training, the evidence is limited. There is a lack of data in the literature regarding the effects of fasting on resistance exercises and whether this practice may reflect in losses or improvements in morphological and neuromuscular adaptations related to resistance training. Thus, the aim of the present project is to compare the effects of resistance training performed in the fasted state compared to the fed state during 12 weeks on body composition and physical performance in young adults. Thirty-four eutrophic or overweight individuals, not engaged in regular resistance exercises, aged between 20 and 40 years, will be recruited. They will be put on a standard customized diet and will perform 2 weekly sessions of resistance exercise after overnight fasting (10 to 12 hours) or in the fed state, for 12 weeks. Before, in the middle and after this period, evaluations of body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be analyzed. Comparisons will be performed using Generalized Estimating Equations (GEE), adopting the factors group (2 stratifications) and time (3 stratifications). All results will be expressed as mean and standard deviation and the accepted significance level will be 5%.

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Key information

Conditions

Fasting Behavior Exercise Feeding Behavior Motor Activity Resistance Training

Age range

19 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Escola de Educação Física, Fisioterapia e Dança - UFRGS

Porto Alegre, Rio Grande do Sul, 90690-200, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women;
  • Aged between 19 and 40 years;
  • Body mass index (BMI) between 18 and 29.9 kg/m²;
  • Not engaged in regular strength physical exercise (>1 weekly session) for the last 3 months.

Exclusion criteria

  • Smokers;
  • Use of medications and/or supplements that may influence the outcomes evaluated;
  • Individuals who have a chronic disease that may prevent physical exercise.

Treatment and study plan

Resistance training in the fasted state

Other

On the first day of evaluations, the subjects will perform the basal metabolic rate (BMR) analysis, as well as familiarization with the neuromuscular tests. After the preliminary tests, the volunteers will perform the pre-intervention procedures. Assessments of body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be performed. In addition, instruments related to dietary control and physical activity level will be applied. Subsequently, in a randomized manner, participants will be allocated to one of two different interventions. During the intervention (8 weeks), the adherence to the standard diet will be verified, as well as body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be reassessed. After the 12 weeks of intervention, the volunteers will perform the evaluations referring to the post-intervention moment, following the same steps of the pre-intervention collections.

Other names: Fasting, Strength training

Resistance training in the fed state

Other

On the first day of evaluations, the subjects will perform the basal metabolic rate (BMR) analysis, as well as familiarization with the neuromuscular tests. After the preliminary tests, the volunteers will perform the pre-intervention procedures. Assessments of body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be performed. In addition, instruments related to dietary control and physical activity level will be applied. Subsequently, in a randomized manner, participants will be allocated to one of two different interventions. During the intervention (8 weeks), the adherence to the standard diet will be verified, as well as body composition, muscle thickness and quality, maximum dynamic strength and maximum power will be reassessed. After the 12 weeks of intervention, the volunteers will perform the evaluations referring to the post-intervention moment, following the same steps of the pre-intervention collections.

Other names: Feeding, Strength training

Primary outcomes

  1. Body mass

    Time frame: 1 minute

    Body mass will be measured using a scale (Urano, Canoas, Brazil).

  2. Lean body mass

    Time frame: 15 minutes

    Lean body mass will be determined using the dual energy X-ray absorption (DEXA) method, using a densitometry machine (Hologic GE, Bedford, USA).

  3. Fat body mass

    Time frame: 15 minutes

    Fat body mass will be determined using the dual energy X-ray absorption (DEXA) method, using a densitometry machine (Hologic GE, Bedford, USA).

  4. Muscle thickness

    Time frame: 30 minutes

    Muscle thickness will be evaluated through ultrasound (Nemio XG, Toshiba, Japan).

  5. Muscle quality

    Time frame: 30 minutes

    Muscle quality will be evaluated through echo intensity of the quadriceps through ultrasound (Nemio XG, Toshiba, Japan).

  6. Maximum dynamic strength

    Time frame: 30 minutes

    Maximum dynamic strength will be assessed using the 1 repetition maximum (1RM) test for bench press and knee extension exercises.

  7. Maximum power

    Time frame: 30 minutes

    The maximum power and the medium power will be evaluated in the bench press and knee extension exercises considering a load of 30 and 70% of 1RM.

Sponsors and collaborators

Lead sponsor

Federal University of Rio Grande do Sul

Other

Registry information

Official study title

Effects of Resistance Training Performed in the Fasted State Compared to the Fed State on Morphological and Neuromuscular Adaptations in Young Adults

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Aug 1, 2022
Registry last updated
May 9, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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