Skip to main content
OpenTrials
Completed

NCT Number: NCT03921853

Resistance Training in Patients With Morbid Obesity

The researchers will conduct a study for avoiding the metabolic syndrome in morbid obese patients. Thus, the aim of the present will be determine the effects of a resistance training programme (RT) in preventing or attenuating metabolic syndrome (MetS) in patients with morbid obesity. A second aim will be report the prevalence of non-responders in terms of improvements in MetS markers and other co-variables considered.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Morbid Obesity Behavior Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Motor Activity Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Morbid Overnutrition Overweight Pathological Conditions, Signs and Symptoms Physical Activity Risk Factor, Cardiovascular Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Cristian ALvarez

Osorno, Llanquihue, 5290000, Chile

About this study

The prevalence of metabolic syndrome (MetS) and cardiovascular disease is expected to rise along with the global obesity epidemic. MetS is a cluster of clinical risk factors, including abdominal (visceral) obesity, hypertension, elevated serum triglycerides, low serum high-density lipoprotein (HDL) and hyperglycaemia.The MetS for example, significantly decreases the life expectancy of individuals with morbid obesity and increases the disease burden and economic costs associated with healthcare. In this sense, more recently, there was reported that body mass index (BMI) and fat distribution showed higher associations with inflammation, fat indices, and more prevalence of MetS in morbidly obese subjects, claiming for an early prevention of the MetS in the morbid obese state.

Exercise training has proven to be effective in inducing a clinically significant weight loss and reducing cardiovascular risk. Exercise have reported to be associated with increased muscle mass, decreased body fat, and improved metabolic profile (i.e., improved glucose control and lipid levels). In addition, supervised RT improved muscle strength and functional capacity in patients with obesity undergoing bariatric surgery. However, although RT has been widely studied in obesity, there is little information in the morbid obesity. On the other hand, there is poor knowledge similarly, about the interindividual variability to exercise training in terms of responders and non-responders (NR). Thus, considering the poor knowledge about the MetS prevention in morbid obese patients, as well as the little information about Responders and Non-Responders for improving MetS outcomes, the aim of this study will be determine the effects of a RT program on cardio-metabolic outcomes of MetS in patients with morbid obesity. A second aim will be report the prevalence of non-responders in terms of the effects of resistance training on MetS markers and other health-related variables.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inclusion criteria

  • Older than 18 and younger and ≤65 years of age.
  • With risk factors to Metabolic syndrome
  • With obesity and morbid obesity condition
  • Medical authorization by a physician.

Exclusion criteria

  • Physical limitations (e.g., restricting injuries of the musculoskeletal system, or dependent of a third person).
  • Exercise-related dyspnoea or respiratory alterations.
  • Chronic heart disease with any worsening in the last month.
  • Adherence rate of less than 80% of the total interventions.

Treatment and study plan

Behavioral

Other

The 20-week RT program will consist of three sessions per week, each lasting for 1 hour that will be applied to both control obese (CG) and morbid obese (MO) group. All sessions will start with 15 minutes warm-up with continuous walking and joint mobility and flexibility exercises, 5 minutes of cool down and stretching, in order for preventing injuries. Sessions will include 4 to 8 RT exercises targeting different muscle groups; 1. forearm, 2. knee flexors and 3. extensors, 3. trunk, 4. chest, 5. shoulder elevators, 6. horizontal shoulder flexors and 7. extensors, and 8. plantar flexors. The exercises for each muscle group will be performed in 3 sets of as many repetitions (continuous concentric/eccentric voluntary contraction) possible in 1 minute followed by 2.0 minutes of passive recovery. Before the RT program, each participant will be measure using the subjective modified Borg scale (1-10 points), in order of identifying the muscle failure into 1 minute of exercise.

Other names: Resistant training intervention

Primary outcomes

  1. Fasting glucose

    Time frame: Change from Baseline Fasting glucose at 20-weeks of Resistant Training

    Component of the Metabolic Syndrome

  2. High density lipoprotein

    Time frame: Change from Baseline High density lipoprotein at 20-weeks of Resistant Training

    Component of the Metabolic Syndrome

  3. Systolic blood pressure and diastolic blood pressure

    Time frame: from Baseline Systolic blood pressure and diastolic blood after 20-weeks of Resistant Training

    Component of the Metabolic Syndrome

  4. Waist circumference

    Time frame: Change from Baseline Waist circumference at 20-weeks of Resistant Training

    Component of the Metabolic Syndrome

  5. Triglycerides

    Time frame: Change from Baseline Triglycerides at 20-weeks of Resistant Training

    Component of the Metabolic Syndrome

Secondary outcomes

  1. Body mass index

    Time frame: Change from Baseline Body mass index at 20-weeks of Resistant Training

    Anthropometric

  2. Body mass

    Time frame: Change from Baseline Body mass at 20-weeks of Resistant Training

    Anthropometric

  3. Total cholesterol

    Time frame: Change from Baseline Total cholesterol at 20-weeks of Resistant Training

    Measured by plasma sample

  4. Low density lipoprotein

    Time frame: Change from Baseline Low density lipoprotein at 20-weeks of Resistant Training

    Measured by plasma sample

  5. Six minutes walking test

    Time frame: Change from Baseline Six minutes walking test density lipoprotein at 20-weeks of Resistant Training

    Endurance performance

  6. One maximum repetition of biceps curl

    Time frame: Change from Baseline One maximum repetition of biceps curl at 20-weeks of Resistant Training

    Strength Performance

  7. Handgrip muscle strength

    Time frame: Change from Baseline Handgrip muscle strength at 20-weeks of Resistant Training

    Muscle strength

Sponsors and collaborators

Lead sponsor

Universidad de Los Lagos

Other

Collaborators

  • Universidad de La Frontera

Registry information

Official study title

Preventing Metabolic Syndrome in Patients With Morbid Obesity by Resistance Training: Reporting Non-responder Prevalence

Acronym: ExinMO

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Apr 19, 2019
Registry last updated
Apr 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.