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Completed

NCT Number: NCT05092061

Resistance Training in Adults With Obesity

The purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. The project will include 30 adults with obesity (defined as BMI ≥ 30 or abdominal obesity according to the International Diabetes Federation). In the acute phase blood lactate, heart rate, enjoyment and perceived exertion will be assessed after the two resistance training protocols. In addition, the mean 24-h blood glucose concentration after exercise will be compared between the two protocols.

For the long-term effects blood markers of cardiometabolic health, blood pressure, body composition, objectively measured physical activity and physical fitness will be assessed before and after the intervention. Also, perceived health-related quality of life will be assessed before and after the intervention.

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Key information

Conditions

Overweight and Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Circulation and Medical Imaging

Trondheim, 7491, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obesity (BMI ≥ 30) or
  • Central obesity (defined according to the International Diabetes Federation).

Exclusion criteria

  • Unstable angina
  • recent cardiac infarction (last 4 weeks)
  • uncompensated heart failure
  • severe valvular illness
  • pulmonary disease
  • uncontrolled hypertension
  • kidney failure
  • orthopaedic/neurological limitations
  • cardiomyopathy
  • planned operations during the research period
  • participation in a parallel study

Treatment and study plan

Moderate-repetition resistance training

Other

Will undertake resistance training with moderate loads, and moderate repetitions 3 times per week for 7 weeks.

High-repetition resistance training

Other

Will undertake resistance training with low loads, and high repetitions 3 times per week for 7 weeks.

Primary outcomes

  1. Glycated haemoglobin (HbA1c)

    Time frame: 7 weeks

Secondary outcomes

  1. Fasting glucose

    Time frame: 7 weeks

  2. Blood lipid concentration

    Time frame: 7 weeks

  3. C-reactive protein

    Time frame: 7 weeks

  4. Systolic blood pressure

    Time frame: 7 weeks

  5. Diastolic blood pressure

    Time frame: 7 weeks

  6. Body fat

    Time frame: 7 weeks

    Measured by bioelectrical impedance (InBody 770)

  7. Fat-free mass

    Time frame: 7 weeks

    Measured by bioelectrical impedance (InBody 770)

  8. Body mass

    Time frame: 7 weeks

    Measured by bioelectrical impedance (InBody 770)

  9. Visceral fat area

    Time frame: 7 weeks

    Measured by bioelectrical impedance (InBody 770)

  10. Waist circumference

    Time frame: 7 weeks

  11. VO2max (maximal aerobic capacity)

    Time frame: 7 weeks

  12. Rate of force development

    Time frame: 7 weeks

    Measured by Kistler force plate

  13. Muscular strength (1RM)

    Time frame: 7 weeks

    Leg press and bench press

  14. Muscular endurance

    Time frame: 7 weeks

    Maximum number of repetitions using 50% of 1-RM

  15. Physical activity

    Time frame: Baseline (before intervention), 4 and 7 weeks.

    Assessed at three timepoints throughout the intervention using SenseWear armband activity monitors and/or Personal Activity IntelligenceTM (using heart rate monitors and smart phone application).

  16. Health-Related Quality of Life

    Time frame: 7 weeks

    Using the Short-Form 36 survey and Satisfaction with Physical Function and Appearance Survey

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Registry information

Official study title

Acute and Chronic Effects of Two Different Types of Resistance Training on Cardiometabolic Health in Adults With Obesity

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Oct 25, 2021
Registry last updated
May 26, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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