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Completed

NCT Number: NCT04906525

Resistance Training Effects on Gut Microbiome and Cardiometabolic Outcomes

The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

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Key information

Conditions

Exercise Intervention Behavior Motor Activity

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Missouri

Columbia, Missouri, 65211, United States

About this study

The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-35 years
  • BMI: 25-45 kg/m2
  • Sedentary lifestyle
  • Consistent diet patterns
  • Weight-stable (<4 kg change over the last 3 mo)
  • Willingness to adhere to resistance training protocol and not change diet
  • Non-smoker >1 year or more

Exclusion criteria

  • Disabilities preventing adherence to resistance training protocol
  • Recent start of medications that affect metabolism or appetite
  • Antibiotics
  • Diabetes
  • Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
  • Uncontrolled hypertension and blood pressure ≥ 180/110
  • Gastrointestinal disease and/or bariatric surgery
  • Smoking
  • Illicit drug use
  • Pregnant or lactating individuals

Treatment and study plan

Resistance training

Behavioral

Participants will undergo 6 weeks of supervised resistance training

Conventional physical activity guidelines

Other

Participants are given recommendations on physical activity guidelines

Primary outcomes

  1. Change in stool microbiome diversity

    Time frame: Change over 6 weeks

    16s rRNA sequencing

  2. Change in stool microbiome composition

    Time frame: Change over 6 weeks

    16s rRNA sequencing

Secondary outcomes

  1. Change in blood pressure

    Time frame: change over 6 weeks

    diastolic and systolic blood pressure

  2. Fat mass

    Time frame: Change over 6 weeks

    body composition

  3. Fat free mass

    Time frame: Change over 6 weeks

    body composition

  4. Change in fasting glucose

    Time frame: change over 6 weeks

    Fasting Glucose

  5. Change in glucose regulation

    Time frame: change over 6 weeks

    2 hour glucose clearance

  6. Hip circumference

    Time frame: change over 6 weeks

    anthropometrics

  7. Waist circumference

    Time frame: change over 6 weeks

    anthropometrics

  8. Physical activity

    Time frame: change over 6 weeks

    kcalories burned during free living activity measured by accelerometer

  9. Sleep Quality

    Time frame: change over 6 weeks

    Measured using actigraphs

  10. Sleep Duration

    Time frame: change over 6 weeks

    Measured using actigraphs

  11. 24hr appetite ratings

    Time frame: Once at baseline and at the end of 6 week intervention

    Subjective rating using visual analog scales

  12. Change in Body mass

    Time frame: change over 6 weeks

    Measured in kg

  13. Short chain fatty acids

    Time frame: Change over 6 weeks

    Acetate, propionate, and butyrate

Other outcomes

  1. Food environment perceptions

    Time frame: baseline and at the end of 6 week intervention

    subjective and objective questionnaires

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Registry information

Official study title

Effects of 6-week Resistance Training Intervention on Gut Microbiome and Cardiometabolic Outcomes in Adults With Overweight and Obesity

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
May 28, 2021
Registry last updated
Mar 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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