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Completed

NCT Number: NCT06372080

Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults

The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women.

The main questions it aims to answer are:

* Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone? * Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone?

Participants will be randomly assigned to collagen or placebo groups. Participants will perform resistance training three times per week for 10 weeks and hydrolyzed collagen or maltodextrin will be given to collagen or placebo group respectively immediately before each resistance training session. Also, vitamin C will be given to both groups.

Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mechanical, and material properties of the patellar tendon and vastus lateralis muscle size and architecture will be assessed.

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Key information

Conditions

Healthy Participants Exercise Training Nutrition

Age range

18 year–39 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Research Institute for Sport and Exercise Sciences

Liverpool, Merseyside, L3 3AF, United Kingdom

About this study

Young, healthy, active men and women will ingest 30 grams of hydrolyzed collagen or a calorie matched beverage (maltodextrin) alongside vitamin C prior to performing high-intensity resistance training 2 - 3 times per week for 10 weeks.

The aim of this study is to investigate the effect of combining hydrolyzed collagen supplementation with resistance training in young men and women. If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance.

The experimental design and measurements will be the same in the Arm 1 and Arm 2 but the differences will be sex where participants in Arm 1 will be healthy young men while participants in Arm 2 will be healthy young women.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy young male or female
  • No history of patellar tendon injuries in the past 6 months
  • No history of lower limb musculoskeletal injuries in the past 6 months
  • Non-smokers (including e-cigarettes)
  • Free from cardiovascular and metabolic diseases
  • Nullipara (a woman who has never given birth)

Exclusion criteria

  • Age less than 18 years or higher than 40 years
  • Being vegan or vegetarian (due to the mammalian source of collagen)
  • Consumption of nutritional supplementation that purportedly affects muscle-tendon adaptation or recovery (i.e. protein powder, vitamin C, collagen)
  • BMI over 30 kg/m2
  • Previous anterior cruciate ligament injury where the patellar tendon was used as a graft

Treatment and study plan

Resistance training with hydrolyzed collagen ingestion in healthy young men

Dietary Supplement

Participants in this intervention will be healthy young men. The information of nutritional supplements is below.

Hydrolyzed collagen: 30 grams unflavored hydrolysed collagen (HC) (Myprotein, Cheshire, UK) 30.5 grams unflavored maltodextrin (Myprotein, Cheshire, UK) 50 milligrams vitamin C powder (Holland and Barrett Retail Limited, Warwickshire, UK) 3 grams non-caloric sweetener (Truvia®, SilverSpoon, London, UK)

Resistance training with hydrolyzed collagen ingestion in healthy young women

Dietary Supplement

Participants in this intervention will be healthy young women. The same nutritional supplements in Arm 1 wil be used in Arm 2.

Primary outcomes

  1. Maximal knee extensor (quadriceps) muscle strength

    Time frame: 12 weeks (10 weeks' intervention plus one week either side for assessments)

    Using isokinetic dynamometer, knee extensor maximal isometric voluntary contraction torque (in Newton meters) will be measured.

  2. Maximal knee flexor (hamstring) muscle strength

    Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)

    Using an isokinetic dynamometer, knee flexor maximal isometric voluntary contraction torque (in Newton meters) will be measured.

  3. Patellar tendon cross-sectional area

    Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)

    Using ultrasonography, patellar tendon cross-sectional area (in millimeters squared) will be measured.

  4. Patellar tendon stiffness

    Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)

    Using ultrasonography, patellar tendon stiffness (in Newtons per millimeter) will be measured.

  5. Vastus lateralis (VL) muscle size

    Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)

    Using ultrasonography, the VL anatomical cross-sectional area (in centimeters squared) will be measured.

  6. Vastus lateralis (VL) muscle fascicle length

    Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)

    Using ultrasonography, VL muscle fascicle length (in millimeters) will be measured.

  7. Vastus lateralis (VL) muscle fascicle pennation angle

    Time frame: 12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)

    Using ultrasonography, VL muscle fascicle pennation angle (in degrees) will be measured.

Sponsors and collaborators

Lead sponsor

Liverpool John Moores University

Other

Registry information

Official study title

The Effects of Resistance Training With Hydrolyzed Collagen Supplementation on Muscle and Tendon Adaptation in Healthy Young Adults

Important dates

Study start
2020
Primary completion
2021
Study completion
2023
First posted
Apr 17, 2024
Registry last updated
Apr 17, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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