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OpenTrials
Completed

NCT Number: NCT00742430

Resistance on Antithrombotic Drugs in Ischemic Heart Disease

The purpose of this study is to determine whether aspirin and clopidogrel resistance measured with Multiplate function analyser has a good correlation with incidence of major adverse cardiac events in patients with coronary artery disease (CAD).

Completed

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinic of Cardiovascular Diseases, Clinical Medical Centre Rebro

Zagreb, 10000, Croatia

About this study

Our plan is to enroll 180 patients with diagnosed CAD who electively undergo percutaneous coronary intervention (PCI). Blood samples will be taken just before the procedure and one day after the procedure and analysed on Multiplate function analyser. Assessing aspirin and clopidogrel resistance incidence using Multiplate platelet function analyzer we will also try to find resistance correlation with the incidence of major adverse cardiac events in a one year follow up.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective PCI
  • > 7 days on aspirin 100mg therapy before the intervention
  • > 7 days on clopidogrel 75mg therapy before the intervention

Exclusion criteria

  • Loading dose of clopidogrel
  • < 7 days on aspirin therapy before the intervention
  • Myocardial infarction less than 30 days before the intervention
  • Cerebrovascular incident less that three months before the intervention
  • Haemorrhagic diathesis
  • Trc < 100
  • Htc < 30%
  • Creatinine > 140

Treatment and study plan

PCI

Procedure

percutaneous coronary intervention in stable coronary artery disease

Other names: stenting, PTCA, balloon dilatation

Primary outcomes

  1. Major adverse coronary event

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

University of Zagreb

Other

Registry information

Official study title

Assessment of Aspirin and Clopidogrel Resistance in Ischemic Heart Disease Using Multiplate Function Analyser and it's Correlation With Major Adverse Cardiac Events

Important dates

Study start
2009
Study completion
2011
First posted
Aug 27, 2008
Registry last updated
Feb 14, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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