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Completed

NCT Number: NCT06718712

Resistance Exercise Volume and Hypertrophic Response Variability in Elderly

The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).

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Key information

Conditions

Aging Muscle Hypertrophy

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Sao Paulo

São Paulo, 05508-030, Brazil

About this study

The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 60 years and older
  • not engaged in regular resistance and/or aerobic training for at least six months before the intervention

Exclusion criteria

  • diagnosed type I diabetes mellitus
  • arrhythmia
  • noncontrolled hypertension
  • any major orthopedic musculoskeletal condition
  • use of any dietary supplement or drug with potential anabolic effects

Treatment and study plan

Lower body resistance training

Other

The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session.

Primary outcomes

  1. Quadriceps muscle cross-sectional area

    Time frame: 10 weeks

    Quadriceps muscle CSA was obtained through magnetic resonance imaging.

Secondary outcomes

  1. Maximum dynamic strength

    Time frame: 10 weeks

    Unilateral quadriceps 1-RM of both legs were assessed on a knee-extension machine

Other outcomes

  1. Dietary assessment

    Time frame: Before intervention

    Dietary assemment using the USDA Automated Multiple-Pass Method

  2. Mass spectrometry

    Time frame: 10 weeks

    Mass spectrometry metabolomics

  3. Skeletal muscle RNA-sequencing

    Time frame: 10 weeks

    RNA sequencing using an Illumina NovaSeq Platform with a standard paired-end 150 bp (PE150) dual indexing protocol

  4. Muscle protein measures

    Time frame: 10 weeks

    Upstream binding factor (UBF) muscle protein was quantified by Simple Western capillary immunoassay.

  5. Muscle protein measures

    Time frame: 10 weeks

    v-Myc Avian Myelocytomatosis Viral Oncogene Homolog (c-Myc) muscle protein was quantified by Simple Western capillary immunoassay.

  6. Muscle protein measures

    Time frame: 10 weeks

    Frizzled class receptor 1 (Frizzled-1) muscle protein was quantified by Simple Western capillary immunoassay.

  7. Muscle protein measures

    Time frame: 10 weeks

    ribosomal protein L3 (rpL3) muscle protein was quantified by Simple Western capillary immunoassay.

Sponsors and collaborators

Lead sponsor

University of Sao Paulo General Hospital

Other

Collaborators

  • University of Sao Paulo

Registry information

Official study title

Effects of Resistance Exercise Volume on the Variability of the Hypertrophic Response in Elderly

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Dec 5, 2024
Registry last updated
Dec 11, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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