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Completed

NCT Number: NCT03120416

Resistance Exercise Training in Chronic Kidney Disease

The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.

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Key information

Conditions

Chronic Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Illinois at Chicago

Chicago, Illinois, 60612, United States

About this study

Resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (CKD) are limited. The investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. To accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with CKD. The results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with CKD including CKD progression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CKD stage 3 or 4 (eGFR 15-60 ml/min/1.73m2)

Exclusion criteria

  • Currently institutionalized
  • Kidney transplant or dialysis
  • NY Heart Association class 3-4 heart failure
  • Dementia or cognitive impairment
  • Unstable angina or coronary revascularization within the last 3 months
  • Uncontrolled arrhythmia
  • Severe chronic lung disease
  • Orthopedic, neurologic or other condition that would preclude resistance exercise training
  • Pregnancy
  • Uncontrolled hypertension (systolic > 160 mmHg and diastolic >90 mmHg)

Treatment and study plan

Resistance Exercise Training

Behavioral

12-week resistance exercise training program, 2 times per week, 45 min per session. Eight exercises will be used to include large upper and lower body muscle groups (leg press, leg extension, leg curl, chest press, shoulder extension, biceps curl, abdominal crunch and back extension). The baseline one repetition maximum will be used to set initial training loads.

Primary outcomes

  1. Endothelial function

    Time frame: 3 months

    Measured by brachial artery flow-mediated dilation (FMD)

Secondary outcomes

  1. Vascular function

    Time frame: 3 months

    Measured by pulse wave velocity

  2. Carotid artery stiffness

    Time frame: 3 months

    Measured by non-invasive ultrasound

  3. Self-reported physical activity

    Time frame: 3 months

    Assessed by the MESA (Multiethnic Study of Atherosclerosis) Typical Week Physical Activity Survey

  4. Objectively measured physical activity

    Time frame: 3 months

    Assessed by a physical activity monitor (ActiGraph GT3X+)

  5. Systolic blood pressure

    Time frame: 3 months

    Measured using standard procedures

  6. Serum LDL-cholesterol

    Time frame: 3 months

    Measured using standard procedures

  7. Serum HDL-cholesterol

    Time frame: 3 months

    Measured using standard procedures

  8. Muscle strength

    Time frame: 3 months

    Assessed by the amount of weight lifted in a single chest press and leg press (1 RM).

Sponsors and collaborators

Lead sponsor

University of Illinois at Chicago

Other

Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  • National Institutes of Health (NIH)

Registry information

Official study title

Effect of Resistance Exercise Training on Endothelial Function and Cardiovascular Risk Factors in Patients With Chronic Kidney Disease

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Apr 19, 2017
Registry last updated
Apr 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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