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Completed

NCT Number: NCT04053920

Resistance Exercise Training at Different Intensities

The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial population that includes both healthy and frail older people.

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Key information

Conditions

Sarcopenia Aging Atrophy Frailty Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

GRI Clinical Research Facility

Glasgow, G12 8TA, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over age of 65 years

Exclusion criteria

  • Current participation in an exercise programme
  • Exercise deemed unsafe by clinical team

Treatment and study plan

Low Load Resistance Exercise

Behavioral

leg extension, leg press, leg curl and calf press

High Load Resistance exercise

Behavioral

leg extension, leg press, leg curl and calf press

Primary outcomes

  1. Muscle strength

    Time frame: Change from baseline to 8 weeks

    Knee extensor maximal torque during an isometric MVC

Secondary outcomes

  1. Vastus lateralis muscle thickness

    Time frame: Change from baseline to 8 weeks

    Measured via ultrasound

  2. Muscle strength

    Time frame: Change from baseline to 8 weeks

    Knee flexor maximal torque during an isometric MVC

  3. One-repetition maximum

    Time frame: Change from baseline to 8 weeks

    leg extension, leg curl, leg press and calf press

  4. Biomechanics during walking and stair climbing

    Time frame: Change from baseline to 8 weeks

    Motion analysis

  5. Short performance physical battery test

    Time frame: Change from baseline to 8 weeks

    SPPB - balance, walking pace and chair rise

  6. Quality of life measure

    Time frame: Change from baseline to 8 weeks

    EQ-5D-5L questionnaire

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Aug 13, 2019
Registry last updated
Mar 25, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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