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Completed

NCT Number: NCT05321914

Resistance Exercise, Metabolism and Time of Day

The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives:

1. Compare the effects of resistance exercise training performed in the morning vs the evening on insulin sensitivity 2. Compare the effects of resistance exercise training performed in the morning vs the evening on gains in muscle mass and strength 3. Compare the acute glucose responses to resistance exercise performed in the morning vs the evening

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Key information

Conditions

Metabolic Disease Behavior Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stuart Robert Gray

Glasgow, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • pass the physical activity readiness questionnaire
  • body mass index (BMI) >27kg/m² and limited to 40 kg/m².

Exclusion criteria

  • Prior surgery for weight loss
  • Prior history of heart, lung, cancer, endocrine or liver disease
  • Participating in more than 1 hour structured exercise training per week

Treatment and study plan

Exercise Training

Behavioral

Exercise will consist of 1 set x 9 exercises x 3 sessions per week x 6 weeks. The load to be used during training will be calculated as 80% of one-repetition maximum (1RM) with each set performed to failure. 1RM will be re-tested on week 3, and the load adjusted accordingly, and upon completion of the study. During the training period, all sessions of training will be supervised by the researcher. The following exercises will be performed: Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise.

Primary outcomes

  1. Change in insulin sensitivity

    Time frame: Change from baseline to 6 weeks

    Insulin sensitivity calculated via the Matsuda Index during an oral glucose tolerance test

Secondary outcomes

  1. Change in vastus lateralis muscle thickness

    Time frame: Change from baseline to 6 weeks

    Muscle thickness of the vastus lateralis muscle measured via ultrasound

  2. Change in whole body lean mass

    Time frame: Change from baseline to 6 weeks

    whole body lean mass measured via bio-electrical impedance

  3. Change in whole body fat mass

    Time frame: Change from baseline to 6 weeks

    whole body fat mass measured via bio-electrical impedance

  4. Change in one-repetition maximum muscle strength

    Time frame: Change from baseline to 6 weeks

    Sum of one-repetition maximum of Bench press, biceps curl, lat pull down, overhead press, lateral raise, leg extension, leg curl and calf raise exercise

  5. Change in knee extensor maximal isometric torque

    Time frame: Change from baseline to 6 weeks

    Knee extensor maximal isometric torque measured during a maximal voluntary contraction

  6. Change in grip strength

    Time frame: Change from baseline to 6 weeks

    Grip strength measured with a hand held dynamometer

  7. Change in mean glucose levels

    Time frame: Change from baseline to 6 weeks

    Mean glucose levels measured via continuous glucose monitors

  8. Change in glucose variability

    Time frame: Change from baseline to 6 weeks

    Glucose variability measured via continuous glucose monitors

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

The Impact of the Time of Day on Metabolic Responses to Resistance Exercise in Adults Who Are Obese or Overweight: a Randomised Controlled Trial

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Apr 11, 2022
Registry last updated
Mar 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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