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Completed

NCT Number: NCT05026541

Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators

This study aims to investigate the effect of a 15-minute meditation practice on sleep architecture and high-frequency Heart Rate Variability (HF-HRV), as well as cognitive performance after both a well-rested and sleep-deprived night.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Beth Israel Deaconess Medical Centre

Boston, Massachusetts, 02215, United States

About this study

Sleep is physiologically important for memory consolidation, mood and hormonal regulation, and maintaining low levels of systemic inflammation. However, a substantial proportion of people are reported to regularly sleep less than the recommended 7-9 hours a night. Meditation may be a means to mitigate the negative effects of sleep deprivation, as many types of meditations are associated with increasing high-frequency heart rate variability (HF-HRV), which is an index of parasympathetic control of the heart. Greater parasympathetic drive may be associated with physiological buffering of the detrimental effects of sleep deprivation.

The investigators want to conduct a prospective cohort study where subjects practice a 15-minute meditation (Shoonya meditation) or continue their usual routine. Subjects will be asked to complete some cognitive tests before and after a night of sleep and a night of sleep deprivation. During the night of sleep, participants will undergo polysomnography recording for sleep architecture and quality.

The intervention group and the control group, which continues their usual routine, will only undergo one visit.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Shoonya meditation program participants/individuals eligible to participate who are healthy adults of age 18 or older, and reside in the United States. Participants must be able and willing to travel to Boston.
  • Nap Group: Healthy adults of age 18 or older that reside in the United States, nap regularly (at least 3 times a week), and do not meditate regularly.

Exclusion criteria

  • History of any neurological condition (i.e. Parkinson's disease, Alzheimer's disease, Huntington's disease, brain tumors, brain surgery, or multiple sclerosis)
  • History of any psychiatric disorder, within last 5 years (i.e. anxiety, psychosis, posttraumatic stress disorder, attention deficit hyperactive disorder)
  • Current use of cognition enhancing medications
  • Active history (within the last 5 years) of alcohol or drug abuse (> 10 drinks per week)
  • History (within the last 5 years) of stroke/aneurysm
  • Recent history (< 3 months) of seizures
  • 60 years of age or older
  • History of Heart Attack and Ejection Fraction less than or equal to 30%
  • Pregnancy
  • Non-English speaking
  • History/Diagnosis of any sleep disorder
  • Consumption of 3 or more cups of coffee a day
  • Previously learned shoonya meditation (for the meditator groups)

Treatment and study plan

Nap Practitioners

Behavioral

Regular nappers will be given a 30 minute nap opportunity to nap for as long as they please.

Shoonya Meditation

Behavioral

This is a 15 minute meditation, described as a process of conscious non-doing.

Primary outcomes

  1. Error frequency Change: Go-No Go Task

    Time frame: 2 months post learning meditation

    The primary outcome is the difference in number of commission and omission errors on the Go-No Go task. The difference in scores pre- and post-sleep deprivation will be analyzed between the control and intervention group.

Secondary outcomes

  1. Reaction Time Change: Go-No Go

    Time frame: 2 months post learning meditation

    The difference in reaction times on the Go-No Go task. The difference in scores pre- and post-sleep deprivation will compared between the control and intervention groups.

Sponsors and collaborators

Lead sponsor

Beth Israel Deaconess Medical Center

Other

Registry information

Acronym: REST

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Aug 30, 2021
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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