Skip to main content
OpenTrials
Enrolling by Invitation

NCT Number: NCT05124132

Resilience and Brain Health of Older Adults (MEDEX-2)

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Enrolling by Invitation

Interested in participating?

Request Info

Key information

Conditions

Age-related Cognitive Decline Behavior Motor Activity

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participated in the parent study, Protocol ID #201410093

Exclusion criteria

  • Inability to safely continue classes or complete assessments, as per PI discretion

Treatment and study plan

Mindfulness-Based Stress Reduction

Behavioral

Mindfulness-Based Stress Reduction

Exercise

Behavioral

Exercise

Mindfulness-Based Stress Reduction + Exercise

Behavioral

Mindfulness-Based Stress Reduction + Exercise

Health Education

Behavioral

Health Education

Primary outcomes

  1. Effects of the interventions on changes in cognitive performance

    Time frame: Approximately three years

    Test effects of mindfulness and exercise on changes in change in memory and cognitive control composites.

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Collaborators

  • National Institute on Aging (NIA)
  • National Institutes of Health (NIH)
  • University of California, San Diego

Registry information

Acronym: MEDEX-2

Important dates

Study start
2019
Primary completion
2026
Study completion
2027
First posted
Nov 17, 2021
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.