Residence Time Evaluation of Marketed OTC Ophthalmic Products

Inclusion criteria

• Informed consent and HIPAA read, signed and dated before conducting any procedures.
• Adult volunteers diagnosed with mild to moderate dry eye. Criteria for diagnosis must include 2 of the 3 following characteristics: composite symptom score > or = to 5 on modified Schein questionnaire; NaFl TFBUT < or = to 7 seconds in either eye; or NaFl corneal staining sum score > or = to 3 (using 0-15 point grading system).
• Able and willing to follow study instructions. 4) Best-corrected V.A. of 0.6 logMAR or better OU.

Exclusion criteria

• History or evidence of ocular or intraocular surgery in either eye w/i the past 6 months.
• History or evidence of serious ocular trauma in either eye w/i the past 6 months.
• History of intolerance or hypersensitivity to any component of the study medications.
• History or evidence of epithelial herpes simplex keratitis, vaccinia, active or recent varicella viral disease of the cornea and/or conjunctiva and/or eyelids, mycobacterial infection of the eye, and/or fungal disease of the eye.
• Use of concomitant topical ocular medications during the study period.
• Patients using systemic medications that may contribute to dry eye may not be enrolled unless they have been on a stable dosing regimen for a minimum of 30 days prior to Visit 1, and the dosing regimen must remain stable throughout the study period.
• Ocular conditions such as conjunctival infections, iritis, or any other ocular condition that may preclude the safe admininstration of the test article.
• Individuals unwilling to d/c contact lens wear during the study period. CL wear must have been d/c at least one week prior to Visit 1.
• Participation in an investigational drug or device study w/i 30 days of entering this study.
• Additionally, any subject may be declared ineligible for a valid medical reason.