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OpenTrials
Completed

NCT Number: NCT05061199

Resection Margin of Transverse Colon Cancer With Extracorporeal Versus Intracorporeal Anastomosis

The approach of anastomosis in laparoscopic resection of transverse colon cancer (TCC) has rarely been discussed. This study aims to compare the resection margin of TCC with extracorporeal anastomosis (ECA) versus intracorporeal anastomosis (ICA).

Patients who underwent laparoscopic resection of TCC from August 2019 to July 2021 in 13 participating centers are included in this study. According to the approach of anastomosis, patients are divided into two groups, ECA group and ICA group respectively. The clinical characteristics, the perioperative outcomes and the pathological results (especially the length of resection margin) are compared between the two groups. The length of two-sided resection margins (long margin, short margin) are measured on formalin-fixed specimens and those with short margin less than 4.0 cm are defined as unqualified specimens.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

Shanghai Minimally Invasive Surgery Center

Shanghai, China

About this study

13 participating centers are as follows: Ruijin Hospital, Shanghai Jiaotong University School of Medicine;Zhejiang University Medical College Affiliated Sir Run Shaw Hospital;Zhongshan Hospital Affiliated to Fudan University;Renji Hospital Affiliated to Medical College of Shanghai Jiaotong University; Jiangsu Provincial People's Hospital; Xiangya Hospital of Central South University; The First Affiliated Hospital of Chongqing Medical University; The first hospital of Jilin University; Beijing Friendship Hospital Affiliated to Capital Medical University; Tangdu Hospital; Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology; Cancer Hospital of Chinese Academy of Medical Sciences; Henan Provincial People's Hospital

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1. pathologically confirmed adenocarcinoma of colon
  • 2. The tumor is located in the transverse colon (including hepatic or splenic flexure);
  • 3. One of the following procedures was performed: transverse colectomy, right hemicolectomy, enlarged right hemicolectomy, left colectomy, enlarged left colectomy;
  • 4. Laparoscopic surgery (laparoscopy-assisted surgery or complete laparoscopic surgery) from August 2019 to July 2021;
  • 5. Radical resection (R0) was accomplished;

Exclusion criteria

  • 1. Simultaneous multiple colorectal cancer;
  • 2. history of colorectal surgery (except endoscopic surgery);
  • 3. robot-assisted surgery;
  • 4. palliative resection (non-R0 resection) or palliative bypass;
  • 5. the approach of anastomosis could not be determined from the documents;
  • 6. the length of resection margin was not recorded in pathological report;

Treatment and study plan

approach of anastomosis

Procedure

The approach of anastomosis

Primary outcomes

  1. length of the resection margin

    Time frame: one month after surgery

    length of the two -sided resection margins measured on formalin-fixed specimen (CM)

Sponsors and collaborators

Lead sponsor

Shanghai Minimally Invasive Surgery Center

Other

Registry information

Official study title

The Impact of Intracorporeal Anastomosis on Resection Margin During Laparoscopic Radical Resection of Transverse Colon Cancer: a Retrospective Multi-center Study

Important dates

Study start
2022
Primary completion
2022
Study completion
2023
First posted
Sep 29, 2021
Registry last updated
Mar 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.