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Enrolling by Invitation

NCT Number: NCT07247877

Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension

The objective of this observational study is to compare the safety profile of auxiliary liver transplantation using small-for-size grafts with that of conventional liver transplantation and to evaluate the efficacy of this technique. The primary research question it seeks to investigate is:

"What are the differences in safety and efficacy between auxiliary liver transplantation utilizing small-for-size grafts and conventional liver transplantation for the treatment of portal hypertension?"

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Key information

Conditions

Liver Transplantation

Age range

14 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 14 years.
  • Presence of decompensated portal hypertension.
  • Meeting the indications for liver transplantation surgery.
  • International Normalized Ratio (INR) < 2.4.
  • Scheduled to undergo orthotopic auxiliary partial liver transplantation or conventional liver transplantation.

Exclusion criteria

  • Rare liver-related anatomical variations.
  • Presence of contraindications to liver transplantation combined with malignant tumors.
  • Grade III or higher portal vein thrombosis.
  • Severe systemic diseases unrelated to the etiology or complications of portal hypertension.
  • Special surgical procedures such as dual-graft liver transplantation.
  • Special graft sources including domino liver transplantation.
  • Liver re-transplantation.

Treatment and study plan

Primary outcomes

  1. overall survival

    Time frame: Within one year after liver transplantation

  2. Complications

    Time frame: Within one year after liver transplantation

  3. portal hypertension resolution

    Time frame: Within one year after liver transplantation

Sponsors and collaborators

Lead sponsor

Zhi-Jun Zhu

Other

Registry information

Official study title

Innovative Technology Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension

Important dates

Study start
2014
Primary completion
2028
Study completion
2029
First posted
Nov 25, 2025
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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