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NCT Number: NCT06966882

Research on the Real-World Community Application of Large Language Models

There is an imbalance between the supply and demand of eye care services, especially in local communities and remote areas. To address this, it's important to use new intelligent technologies to expand the reach of eye disease screening and treatment. Large language models (LLMs) are a type of deep learning technology that can learn from large amounts of text and generate human-like language to help with medical tasks such as diagnosing diseases and answering health-related questions. The investigator's team has previously developed a localized LLM capable of answering ophthalmology-related medical questions. Building on this, this study plans to use a screening-based trial design to explore how accurately the LLM can make referral decisions for eye diseases, diagnose conditions, recommend appropriate tests, and receive user feedback in real-world community settings. The goal is to improve the ability to screen for eye diseases in grassroots and regional areas.

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Key information

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants of any age and gender
  • Belonging to one of the following ophthalmic categories: Patients requiring specialist referral;Patients manageable at community level;Individuals without ocular pathology
  • Voluntary participation with written informed consent

Exclusion criteria

  • Investigator-determined clinical contraindications

Treatment and study plan

Primary outcomes

  1. Metrics for Evaluating Referral Accuracy of Large Language Models: Sensitivity, Specificity, Accuracy, Positive Predictive Value, Negative Predictive Value.

    Time frame: through study completion, up to 1 year.

Study contacts

Contact information is provided by the study sponsor or research team.

Haotian Lin

CONTACT

[email protected]

86-13802793086

Mingjie Luo

CONTACT

[email protected]

86-18200202414

Sponsors and collaborators

Lead sponsor

Zhongshan Ophthalmic Center, Sun Yat-sen University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 13, 2025
Registry last updated
May 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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