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Active, Not Recruiting

NCT Number: NCT07080320

Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations

The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region. This study will validate MoCap as a tool for quantifying these properties, comparing it to traditional reference tools, and exploring how these properties evolve with age and external treatments. It will also assess MoCap's ability to detect the effects of various treatments such as tightening products and massages. Ultimately, this research will provide a deeper understanding of skin dynamics in the periorbital region and offer insights into both medical and cosmetic applications.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Facial Skin Aging Motion Capture Periorbital Region Skin Movement Vertical Jump

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHRU Amiens

Amiens, 80480, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female participants
  • Caucasian, Fitzpatrick skin types I-III
  • BMI between 18.5 and 27, healthy participants
  • Aged 18 to 65 years (inclusive)
  • Not under guardianship or curatorship
  • Informed written consent
  • Social security affiliation
  • Non-smokers for at least 5 years
  • No excessive UV exposure (artificial or natural) in the last 3 weeks prior to the study or during the study

Exclusion criteria

  • Severe skin disorders preventing the application of electrodes or photo-reflective markers
  • Neurovascular history affecting the face
  • Ongoing treatments influencing facial tissues (e.g., corticosteroids)
  • Current sleep disorders
  • Psychiatric conditions or social interaction impairments
  • Inner ear or balance disorders
  • Osteoporosis, recent fractures, or fragile bone conditions
  • Pregnant or breastfeeding women
  • Under guardianship, curatorship, or legal protection

Treatment and study plan

MoCap

Device

For each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used.

The intervention will be Interventions :

  • Recruitment of healthy and pathological subjects.
  • Full-face and macro images of the periorbital region
  • Measurement of periorbital skin properties using MoCap and standard reference tools.
  • Application of a tightening product (aloe vera) and periorbital massage.
  • Measurement of skin response to a vertical jump.

Primary outcomes

  1. maximum displacement (in millimeters) of each marker placed on the face

    Time frame: day 1

    maximum displacement (in millimeters) of each marker placed on the face during standardized movements of the periorbital region

Secondary outcomes

  1. Coefficient of variation of the maximum displacement amplitudes measured during repeated tests for the same movement.

    Time frame: day 1

  2. The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.

    Time frame: day 1

    The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.

  3. The difference in the mean maximum displacement amplitudes (in millimeters) between different age groups

    Time frame: day 1

    The difference in the mean maximum displacement amplitudes (in millimeters) between different age groups

  4. The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massage

    Time frame: day 1

    The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massage

  5. The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).

    Time frame: day 1

    The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).

  6. The difference in the mean maximum displacement amplitudes (in millimeters) before and after applying a tightening product (aloe vera).

    Time frame: day 1

    The difference in the mean maximum displacement amplitudes (in millimeters) before and after applying a tightening product (aloe vera).

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: REGARD

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jul 23, 2025
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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