Research on Real-time Proton Therapy Guidance Through Monitoring Proton Range Using All-digital PET

The energy transport process of proton beams after entering biological tissue is observed online via proton knife fully digital PET. The dynamic changes of the delivered dose and action range of proton beams in biological tissue are analyzed, the proton dose distribution is reconstructed, and the energy and position of the targeted ablation by proton beams are determined, so as to realize in-beam online PET monitoring for proton therapy.

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Key information

Conditions

Solid Tumor

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Anhui Provincial Hospital

Hefei, Anhui, 230001, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with solid tumors scheduled to receive proton therapy, with measurable lesions;
Signed the informed consent form.

Exclusion criteria

Patients with a history of radioactive seed implantation;
Patients who cannot understand the purpose of treatment or are unwilling/unable to sign the informed consent form;

Treatment and study plan

proton therapy

Radiation

proton therapy

Primary outcomes

the trajectory and range of the proton beam within the human body

Time frame: 1 day

the three-dimensional dynamic distribution of positron nuclides generated by proton beam irradiation

Sponsors and collaborators

Lead sponsor

Shuanghu Yuan

Other

Registry information

Official study title

Full-Digital PET Enables Real-time Monitoring of Proton Range

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2028
First posted: Mar 4, 2026
Registry last updated: Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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