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NCT Number: NCT02339480

Research on Mechanism of Massage Therapy on Energy Metabolism Disorder of Simple Obesity

This project is to penetrate and consummate the research mechanism of massage therapy on simple obesity. Latest researches indicate that the energy regulation network system of hypothalamus and metabolic disorders on adipocyte may be the pathological bases which result in obesity. The research group have firstly conducted effect studies of massage therapy on model of simple obesity rats and observed some neurobiological mechanism (whole effect mechanism), meanwhile, the team have discussed influences on the development of preadipocyte and function of endocrine with dynamic mechanical stimulation in vitro (local effect mechanism). This research aims at centering on the hypothesis that massage therapy can act on energy regulation network system of hypothalamus specifically, thus regulating the energy metabolic disorders. Then applying functional magnetic resonance imaging (fMRI) to explore whether patients with simple obesity exist abnormality on energy regulation network system of hypothalamus, ascertain mechanisms how massage therapy treat energy metabolism disorders of simple obesity, deepen mechanism study on how massage therapy prevent and treat obesity and enrich the clinical application's scientific connotation that massage therapy treat simple obesity.

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Key information

Conditions

Simple Obesity

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Guiyang College of Troditional Chinese Medicine

Guiyang, Guizhou, 550001, China

About this study

This project will divide in two groups,healthy volunteers and obesity group.Healthy volunteers do not accept any treatment while obesity group need accept massage therapy three times a week,18 times in total.And two groups will be checked by functional magnetic resonance imaging (fMRI), Healthy volunteers for once and obesity group for twice(before treatment, obesity group's image of fMRI will compare with Healthy volunteers' and the image which is taken after treatment)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1.above 20% of the normal weight;BMI≥25.0；F%≥30%;

2.18-60 years old；

3.Patients agreeing and signing the Informed Consent for the study．

Exclusion criteria

  • The individuals do not adhere to the treatment or are with other treatments.
  • Secondary obesity, eg:pituitary diseases, hypothalamic disorder, hypothyroidism, pancreatic diseases，hyperadrenocorticism, postmenopausal obesity etc.
  • Having therapy for obesity in the last two weeks.
  • The individuals with server cardiovascular and cerebrovascular diseases and cancer.
  • Critical patients or patients combined with liver and kidney damage.
  • Individuals with psychosis.
  • Female individuals with pregnancy, lactation and planning a pregnancy in the two months.

Treatment and study plan

Massage therapy

Other

Healthy volunteers do not accept treatment, just to be a control group to compare with obesity group

Primary outcomes

  1. body mass index(BMI)

    Time frame: 6 weeks after treatment

Secondary outcomes

  1. Body Weight

    Time frame: 6 weeks after treatment

  2. waistline

    Time frame: 6 weeks after treatment

  3. hip line

    Time frame: 6 weeks after treatment

  4. thigh line

    Time frame: 6 weeks after treatment

  5. percentage of body fat

    Time frame: 6 weeks after treatment

Other outcomes

  1. image of hypothalamus of functional magnetic resonance imaging (fMRI)

    Time frame: before treatment and 6 weeks after treatment

Sponsors and collaborators

Lead sponsor

Guiyang College of Traditional Chinese Medicine

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jan 15, 2015
Registry last updated
Aug 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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