Requirement of Propofol for Induction of Unconsciousness in Patients With Parkinson's Disease

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.

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Key information

Conditions

Parkinson's Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesiology, Changhai Hospital

Shanghai, Shanghai Municipality, 200433, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia
non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia

Exclusion criteria

ASA score higher than Class III
predicted difficult airway
hearing impairment
inability to corporate with instruction
alcohol or drug abuser
patients refusing to provide informed consent

Treatment and study plan

Primary outcomes

Consciousness status

Time frame: Participants will be monitored during the period of propofol infusion, an expected average of less than 10 min

Consciousness status is evaluated by the observer's assessment of alertness and sedation score (OAA/S).

Sponsors and collaborators

Lead sponsor

Changhai Hospital

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: Nov 28, 2013
Registry last updated: Nov 28, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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