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Completed

NCT Number: NCT03846388

Reproductive Outcome in Assisted Conception Cycles

Infertility is the failure to conceive after regular unprotected sexual intercourse for one year. Primary infertility refers woman who has never conceived, and secondary infertility to one who has had a previous pregnancy.The most frequent causes for infertility are ovulatory disorder or anovulation (27-30%) , tubal factor(20-22%), abnormal semen parameters(45-50%). Unexplained infertility refers to infertile couples in whom standard investigations, including tests of ovulation, tubal patency tests and semen analysis are normal. incidence 15-17% of infertile couples. New guidelines on infertility recommend that women with unexplained infertility should be advised for expectant management for 2 years .If pregnancy is not achieved after this period In vitro fertilization Should be considered. The Fast Track and Standard Treatment trial demonstrated A shorter time to pregnancy and higher per cycle pregnancy rates for In vitro fertilization compared with treatment with oral agents or gonadotropins in Patients with unexplained infertility. Successful pregnancy after assisted reproductive technology is influenced by numerous predictors that have been investigated in the previous years. The central predictors of success are the sperm, oocyte quality and endometrial receptivity. Oocyte quality depends mainly on the age of the woman , and her ovarian reserve. Parameters most commonly studied are the woman's age , her antral follicle count , and laboratory tests including serum randomly done during the menstrual cycle levels at day 3 of the cycle.

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Key information

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Assiut university

Asyut, 71111, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • in vitro fertilization treatment due to many factors including tubal, male, and unexplained factors.
  • body mass index (BMI) (18-35)kg/m2

Exclusion criteria

  • patient age less than 20 and more than 40 years.
  • body mass index less than 18 and more than 35 kg/m2.
  • period of infertility less than 2 years..
  • untreated hyperthyroidism, hypothyroidism, diabetes, hypertension.

Treatment and study plan

follicular stimulating hormone

Diagnostic Test

in the serum of our patients

Anti-mullerian hormone

Diagnostic Test

in the serum of our patients

Basal antral follicle count

Radiation

by ultrasound

Primary outcomes

  1. live birth rate

    Time frame: 12 months

Secondary outcomes

  1. Number of fertilized oocytes

    Time frame: 3 days

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Prediction Of Reproductive Outcome in Assisted Conception Cycles in Women With Unexplained Infertility

Important dates

Study start
2019
Primary completion
2022
Study completion
2022
First posted
Feb 19, 2019
Registry last updated
Jul 25, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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