Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease

Inclusion criteria

• Meet the clinically definite or clinically probable PD according to the MDS 2015 version.
• Chinese Han population (three generations), age greater than or equal to 50 years old, less than or equal to 80 years old, male or female.
• Hoehn-Yahr stages 1-4.
• The dose of levodopa drug therapy was stable three weeks before enrollment and during the follow-up period.
• Right-handed.
• The patient signed a written informed consent.

Exclusion criteria

• Any form of Parkinsonism other than primary PD.
• Those who have received neurosurgical intervention or stereotaxic brain surgery for PD, or have previously received TMS treatment.
• Cognitive dysfunction (MMSE ≤ 24 points) or those who cannot cooperate with the scale score.
• Persons with mental disabilities.
• Pregnant women.
• There are contraindications for rTMS treatment.
• There are contraindications for MRI examination.
• Baseline PSG suggests other sleep disorders such as moderate to severe OSAS; BMI>=30.
• Patients who are addicted to alcohol, taking SSRIs, TCAs, sedative hypnotics, histamine antagonists and other drugs and food that may affect NREM and REM sleep structure.
• Those who are unwilling to participate in the study or unable to sign the informed consent form; and other circumstances that the researcher considers inappropriate to participate in the study.

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