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OpenTrials
Completed

NCT Number: NCT00169689

Repetitive Transcranial Magnetic Stimulation

The study is a prospective, randomized, double-blind sham-controlled study.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Joachim Cordes

Düsseldorf, Rhineland, 40629, Germany

About this study

The principal objective of this trial is to investigate the effect of left prefrontal high frequency rTMS on negative symptoms in schizophrenia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • DSM-IV criteria for schizophrenia
  • age between 18 and 60
  • informed consent
  • right handed patient
  • no change of antipsychotic treatment > 2 weeks before recruitment

Exclusion criteria

  • seizures, epilepsy
  • history of severe head injury
  • status post implantation of a cardiac pacemaker or other electronic devi-ses

Treatment and study plan

rTMS, "repetitive transcranial magnetic stimulation"

Procedure

10 Hz rTMS (10.000 stimuli) over left dorsolateral prefrontal cortex

rTMS

Other

repetitive transcranial magnetic stimulation, 10 Hz, 10.000 stimuli, 2 weeks

Primary outcomes

  1. Clinical Global Impression;

    Time frame: November 2007

Secondary outcomes

  1. Global psychosocial functioning (GAF), PANSS-Negative Subscale,changes in EEG, heart rate variability, cortisol daytime profile, catecholamines, cognitive functioning

    Time frame: November 2007

Sponsors and collaborators

Lead sponsor

Heinrich-Heine University, Duesseldorf

Other

Registry information

Official study title

Therapeutic and Biological Effects of High Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in Schizophrenia

Important dates

Study start
2003
Study completion
2007
First posted
Sep 15, 2005
Registry last updated
Jan 30, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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