Skip to main content
OpenTrials
Completed

NCT Number: NCT06711250

Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation

The current st udy's objective was to validate the repeated effect of i PRF with autogenous bone on the of gingival thickness , width a n d volumetric bone changes durig maxillary alveolar augmentation using cone beam computer tomography (CBCT). Patients and methods:

Completed

Looking for future studies?

Notify Me

Key information

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry , Al Azhar Univeristy For Girls

Cairo, Heliopolis - Cairo, 123456, Egypt

About this study

The study was a randomized clinical study in which participants needed to augment defective ridge were selected from the Outpatient Clinic, Department of Oral Medicine, Periodontology and Diagnosis , Faculty of Dental Medicine for Girls, Al Azhar University. The Research Ethics Committee, Faculty of Dental Medicine for Girls, Al Azhar University (REC code (P. PD 24 19 ) certified this study and a signed informed consent form with approval was obtained from each. Each patient who was enrolled in the study had a complete medical record and a proper clinical examination. These patients had to have a horizontal or vertical alveolar ridge deficiency and have enough bone in the mandibular donor site (external oblique ridge).

However, patients showing any signs of active periodontal disease, on long term corticosteroid therapy, persons taking bone metabolism drugs as well as individuals suffering from any systemic illness that may impact bone repair were excluded from the study.

Patients were assigned to one of two 2 groups, group I or group II. Group I, consisted of patients grafted with autogenous bone graft alone. I n Group II, patients were grafted using autogenous bone combined with repeated injection of i PRF Assessment of the alveolar ridge dimension and the bone block to be harvested preoperatively using CBCT. T he measurements of the alveolar ridge mesio distaly and bucco lingually in mm were determined at the recipient site . It was crucial to visualize the anatomic structures at the osteotomy site, including the alveolar canal, the mental foramina, and the teeth roots present to create ideal bone cutting planes according to the depth and extension of the graft without any injuries to the aforementioned structures.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who have a horizontal or vertical alveolar ridge deficiency

Exclusion criteria

  • patients showing any signs of active periodontal disease
  • patients on long term corticosteroid therapy,
  • patients taking bone metabolism drugs
  • patients suffering from any systemic illness that may impact bone repair

Treatment and study plan

Khoury technique

Procedure

autogenous bone augmentation

khoury technique with i-PRF injections

Procedure

autogenous bone augmentation with repeated i-PRF injections

Primary outcomes

  1. width of the alveolar ridge

    Time frame: baseline, 6 months & 9 months

    CBCT will be used to assess the width of the alveolar ridge

Secondary outcomes

  1. volumetric analysis of bone

    Time frame: at baseline, 6 and 9 months

    volumetric analysis ob bone using CBCT to assess the bone volume

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation :randomized Controlled Clinical Trial

Acronym: I-PRF

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Dec 2, 2024
Registry last updated
Dec 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.