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Completed

NCT Number: NCT00290368

Repeat Nasal Allergen Challenge

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.

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Key information

Conditions

Hayfever Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Nose Diseases Otorhinolaryngologic Diseases Respiratory Hypersensitivity Respiratory Tract Diseases Rhinitis Rhinitis, Allergic Rhinitis, Allergic, Seasonal

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

National Heart & Lung Institute Clinical Studies Unit

London, SW3 6HP, United Kingdom

About this study

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female subjects with a history of seasonal (intermittent) atopic rhinitis, aged 18-40 years.
  • Otherwise healthy with no health problems that may jeopardize the subjects participating in the study, absence of history of other significant allergies.

Exclusion criteria

  • Smokers (use of tobacco products in the previous 3 months).
  • Presence of any respiratory disease other than a history of mild stable asthma not requiring treatment and associated with normal lung function (FEV1 > 80% predicted at screening).

Treatment and study plan

skin prick test

Procedure

Nasal allergen challenge

Procedure

Nasal filter paper placement

Procedure

Nasal lavage

Procedure

Nasal scrape

Procedure

Nasal symptoms score

Procedure

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Collaborators

  • Novartis Pharmaceuticals

Registry information

Official study title

Assessment of Inflammatory Mediator and Cellular Changes Following Repeated Nasal Allergen Challenge in Subjects With Allergic Rhinitis Sensitive to Timothy Grass Pollen - a Validation Study

Important dates

Study start
2006
Study completion
2006
First posted
Feb 13, 2006
Registry last updated
Sep 14, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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