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Completed

NCT Number: NCT04845815

Renal Tubular Disorders in Egyptian Children

Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children.

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Key information

Conditions

Renal Tubular Disorders in Children Acid-Base Imbalance Acidosis Failure to Thrive Hypokalemia Metabolic Diseases Nutritional and Metabolic Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Water-Electrolyte Imbalance

Age range

1 month–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

pediatric department, Sohag university hospital

Sohag, 82516, Egypt

About this study

Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children. As a result, starting management early will help those children have a better life. Therefore awareness about these disorders and long-term outcome is really important. The investigators present the clinical characterizations of many tubular disorder and the follow up in our center.

The aim of this study is to reveal the different clinical presentations and the main lab features of renal tubular disorders in children to promote early recognition and management.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All children aged from one month to 18 years who have renal tubular disorders.

Exclusion criteria

  • Children who have renal tubular disorders secondary to drugs, intoxication, obstructive uropathy or transient in nature.

Treatment and study plan

Primary outcomes

  1. weight

    Time frame: 1 years

    in kilograms

  2. Glomerular function

    Time frame: 1 years

    The glomerular function was assessed by estimated glomerular filtration rate (eGFR) calculated using Schwartz formula. Chronic kidney disease (CKD) was defined in the presence of a permanent reduction in GFR (e-GFR; <60 ml/min/1.73 m2 Kidney Disease Outcomes Quality Initiative < stage 3).

  3. height

    Time frame: 1 years

    in meters

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Patterns of Renal Tubular Disorders in Egyptian Children: a Single Center Study

Important dates

Study start
2021
Primary completion
2021
Study completion
2022
First posted
Apr 15, 2021
Registry last updated
Feb 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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