Necker Hospital
Paris, 75015, France
Completed
NCT Number: NCT00925379
Renal HYPODYSPLASIA : Genetic and Familial Assessment
Evaluation of the frequency of familial cases of renal HYPODYSPLASIA
Completed
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Conditions
Age range
3 month–18 year
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
DNA collection from the propositus and its family. A questionnaire will be filled by the parents to seek other affected individual in the family.With another affected member, DNA collection will be collected from the whole family.
A renal ultrasound will be prescribed for the parents, brothers and sisters.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Children aged more than 3 months and less than 18 years old with a renal bilateral HYPODYSPLASIA set by renal ultrasound examination :
- renal size < -2DS
- with/or hyperechogenicity or lack of cortical-medullary differentiation
- with/or renal cysts
Exclusion criteria
- Bladder uropathy or sus-bladder uropathy
- Recessive or dominant renal polycystic disease
- Bardet-Biedl syndrome and other malformative syndromes except renal coloboma syndrome, Renal cysts and diabetes syndrome RCAD
- Lack of written informed consent
Treatment and study plan
Primary outcomes
-
Evaluation of the heritability of renal HYPODYSPLASIA (on the renal ultra sound) and DNA collection to make possible identification of predisposing genes
Time frame: the same day
Sponsors and collaborators
Lead sponsor
Assistance Publique - Hôpitaux de Paris
Other
Collaborators
- URC-CIC Paris Descartes Necker Cochin
Registry information
Official study title
Renal HYPODYSPLASIA;Study of Familial Cases and Search for Predisposing Genes
Acronym: HDR
Important dates
- Study start
- 2009
- Primary completion
- 2013
- Study completion
- 2014
- First posted
- Jun 22, 2009
- Registry last updated
- Nov 20, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.