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OpenTrials
Completed

NCT Number: NCT01918618

Renal Effects of Levosimendan in Cardiac Surgery Patients

Recent experimental and clinical data suggest a benefit of levosimendan on the kidney function. Therefore, this retrospective, single center, matched-pairs analysis aimed to investigate whether administration of levosimendan was associated with improved renal function in cardiac surgery patients.

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Key information

Conditions

Treatment of Left Heart Insufficiency in an Operative Setting of Cardiac Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Charité - University Medicine Berlin

Berlin, State of Berlin, 10117, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing cardiac surgery (OPS 5-35 bis 5-37) between 2007 and 2011 followed by postoperative observation on an ICU of the anaesthesiology department of the Charité hospital

Exclusion criteria

  • Patients younger 18
  • Preexisting renal insufficiency

Treatment and study plan

Primary outcomes

  1. Change of plasma creatinine (Difference in renal function)

    Time frame: last available value pre-op (baseline), first available value on post-op day 1, 2, 3 and 4

    Only in patients not requiring renal replacement therapy

  2. Change of urine output after surgery (difference in renal function)

    Time frame: post-op day 1, 2, 3, 4

    Only in patients not requiring renal replacement therapy

  3. Cumulative incidence and duration of hemodialysis (Difference in renal function)

    Time frame: last day of hospital stay

Secondary outcomes

  1. Cumulative Length of stay (hospital and ICU)

    Time frame: last day of hospital stay

  2. In-hospital mortality

    Time frame: last day of hospital stay

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Aug 8, 2013
Registry last updated
Aug 8, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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