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Completed

NCT Number: NCT05912673

Renal Doppler in Pediatric Patients With Idiopathic Nephrotic Syndrome

The use of the renal resistive index in pediatric patient with idiopathic nephrotic syndrome to detect steroid resistance and to use it as a prognostic instrument of the progression of the disease.

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Key information

Conditions

Nephrotic Syndrome Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Nephrosis Urogenital Diseases Urologic Diseases

Age range

1 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sara Mabrouk Mohamed Elghoul

Tanta, Egypt

About this study

Renal Doppler will be done for all children in supine and lateral positions using Toshiba Aplio ultrasound machine and renal resistive index will be measured (peak systolic velocity- end diastolic velocity/ peak systolic velocity) at diagnosis, after one month, 3 months and 6months, in which these values will be obtained by the ultrasound machine based on the computer algorithm. Also the kidneys will be scanned firstly for length, width, cortical thickness and echogenicity.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pediatric patients with primary nephrotic syndrome aged from 1 to 18 years

Exclusion criteria

  • - Patients with congenital nephrotic syndrome.
  • Patients with secondary causes of nephrotic syndrome.

Treatment and study plan

renal doppler

Device

Toshiba Aplio ultrasound machine and renal resistive index will be measured (peak systolic velocity- end diastolic velocity/ peak systolic velocity

Primary outcomes

  1. detection of steroid resistance in pediatric patients with idiopathic nephrotic syndrome

    Time frame: 6 weeks

    measurement of renal resistive index and detection of steroid sensitivity

Secondary outcomes

  1. progression of nephrotic syndrome

    Time frame: six months

    frequent measurement of renal resistive index and using it as prognostic factor

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Renal Doppler in Detection of Steroid Resistance in Pediatric Patients With Idiopathic Nephrotic Syndrome

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jun 22, 2023
Registry last updated
Jan 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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