Renal Arterial Resistive Index as a Noninvasive Biomarker of Disease Activity in Lupus Nephritis Patients

Systemic Lupus Erthymatosous (SLE) is achronic inflammatory multi system auto immue disease characterized by pathogenic auto anti bodies production against nuclear structures (Bolouri et al.,2022), SLE affecting mainly woemn of childbearing age and is chracterized by unpredictable flares and remissions , disease variety varied from mild episode disorder to arpidly progressive life -threatening illness..

LN is diagnosed by either the presence of proteinuria >0.5g/day. active urinary sediment , or an unexplained rise in serum creatinine there fore , identifying new invasive biomarkers of LN severity and outcome is mandatory, Renal Arterial resistive index ( RRI) is anon invasive biomarker that has been studied as apotential indicator of disease activity in LN patients.

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Key information

Conditions

Lupus Nephritis Autoimmune Diseases Connective Tissue Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glomerulonephritis Immune System Diseases Kidney Diseases Lupus Erythematosus, Systemic Male Urogenital Diseases Nephritis Skin and Connective Tissue Diseases Urogenital Diseases Urologic Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag university Hospital

Sohag, Egypt

Location status: Recruiting

Location contact

Magdy M Amin, professor

CONTACT

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged ≥18 years.
SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls.
Patients cooperative and can answer questions.
Patients who are able and willing to give written informed consent.

Exclusion criteria

• Individuals with other autoimmune diseases.

Diabetes.
Hypertension.
Heart failure.
Hepatic diseases.
Chronic renal failure.
Renal artery stenosis.
Renal vein thrombosis.
Intrarenal arteriovenous fistula.
Obstructive nephropathy.
Urinary tract obstruction that could affect RI of intra renal arteries.
Un cooperative patients.
Patients not able and willing to give written informed consent.

Treatment and study plan

renal doppler

Diagnostic Test

doppler srudy on renal arteries bilaterally , and detection of RI of renal artery

Primary outcomes

doppler for renal artery

Time frame: 1 year

resistive index of renal artery

Study contacts

Contact information is provided by the study sponsor or research team.

Doaa R Abdelkarim, resident

CONTACT

[email protected]

01027673294

Esam M Abualfadl, professor

CONTACT

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Oct 8, 2024
Registry last updated: Oct 8, 2024

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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