Remote Time-restricted EAting DeliverY

Assessed daily through twice daily automated text messages asking participants to respond with what time they started and stopped eating that day.

Collected via venipuncture

Homeostatic Model Assessment for Insulin Resistance calculated as fasting glucose in mmol/l*fasting insulin in μU/ml/22.5

Participants will be provided with a Dexcom G6 continuous glucose monitor transmitter and sensor. This data will be evaluated as the 5-day average of: 24-hour, daytime, and nocturnal glucose concentration, time in hyper, normo and hypoglycemia, and glycemic variability

Measured via venipuncture and core lab lab analysis

Measured via venipuncture and core lab lab analysis

Measured via Fitbit Aria Air scale at baseline and 16-weeks but also once per week to evaluate trajectory of change

Measured via provided circumference measuring tape as the average of 2 measurements

Participant will be provided with a Bios 3al1-3e blood pressure measuring device. After 5 minutes of quiet seated rest, blood pressure will be measured 6 times, 60 seconds apart in a standardized seated position with the average of the 2nd through 6th measurement used.

Calculated via both the Framingham and Reynolds 10-year CVD risk scores using measured collected for study purposes (i.e., age, total cholesterol, HDL, systolic blood pressure, smoking status, C-reactive protein, family history of heart disease).

As defined by the NCEP/ATP III criteria using measurements taken using provided study tools

As defined by the NCEP/ATP III criteria and age and ethnic specific calculations

Measured via venipuncture and core lab lab analysis

Evaluated via an 'End of Study Survey' (including a Diet Satisfaction Score Tool and acceptability questions) and semi-structured qualitative interviews

Evaluated as uptake of each delivery model, defined as adherence to the intervention touch points (i.e., external support: support calls with staff; peer support: number of peer interactions; both: response rate to adherence).

Intervention costs will be evaluated and averaged per participant from the time required for intervention phone calls, scheduling, and technical support for adherence app by the study staff according to hourly rates of pay.

Evaluated via participant self-report of continued TRE post-intervention

Measured via experience of selected relevant Common Terminology Criteria for Adverse Events (CTCAE v5) with additional questions about duration and change in the revised 18-item version of the Three-Factor Eating Questionnaire (aka Eating Inventory)

Measured by the RAND-36 Physical Component Summary. Physical component summary of the RAND-36 questionnaire (minimum = 0, maximum = 50, a higher score is a better outcome)

Measured via FitBit Inspire 2 as 7-day average

Measured via FitBit Inspire 2 as 7-day average

Measured via FitBit Inspire 2 as 7-day average

Evaluated via the Hospital Anxiety and Depression Scale (HADS); This 14-item questionnaire has a minimum score of 0 and maximum of 21, where a higher score is worse.

Evaluated via the Hospital Anxiety and Depression Scale (HADS); This 14-item questionnaire has a minimum score of 0 and maximum of 21, where a higher score is worse.