Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis

Inclusion criteria

• Age ≥ 40 years old;
• Patients with symptomatic moderate to severe stenosis of the internal carotid artery;
• History of ipsilateral cerebral ischemic symptoms within the past 180 days;
• Planned for carotid artery stent;
• Essen Score ≥ 3;
• Modified Rankin Scale score of 0 or 1;
• Signed informed consent.

Exclusion criteria

• Uncontrolled severe hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg despite medication)
• Subclavian artery stenosis ≥ 50% or presence of subclavian steal syndrome
• Severe hematological disorders or significant coagulation abnormalities
• Contraindications to remote ischemic conditioning, such as severe soft tissue injury, fracture, or vascular injury in the upper limbs, or peripheral vascular disease in the distal upper limbs
• Severe comorbid conditions with a life expectancy of less than 1 year
• Participation in another clinical trial within the past 3 months or ongoing participation
• Any other circumstances deemed by the investigator as unsuitable for participation in this clinical study.