Skip to main content
OpenTrials
Completed

NCT Number: NCT03930589

Remote Ischemic Conditioning in STEMI to Decrease Infarct Size

Following acute STEMI patients may have significant myocardial damage and subsequent heart failure. There is currently conflicting data regarding the benefit of remote ischemic conditioning to decrease the magnitude of infarction. Remote ischemic condition is a process where by repetitive intermittent limb ischemia is used to decrease the magnitude of myocardial damage caused by coronary artery occlusion and the subsequent reperfusion injury in STEMI patients. RemCon-STEMI is a multicenter randomized trial to test the impact of remote ischemic conditioning in acute STEMI.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

STEMI CAD Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients presenting with STEMI within 6 hours of symptom onset and:

  • Are expected to receive reperfusion therapy with either fibrinolysis or primary PCI.
  • Documented informed consent (verbal)

Exclusion criteria

  • Cardiogenic shock
  • History of anatomical deformity or vascular complication that limit ability to conduct remote ischemic preconditioning

Treatment and study plan

Remote Ischemic conditioning

Procedure

BP cuff inflation for 5 min and deflation for 5 mins with 4 cycles

Standard of care

Other

Standard of care

Primary outcomes

  1. Composite of all cause death

    Time frame: 90 days

    all cause death, cardiogenic shock or chf through 90 days

Secondary outcomes

  1. long term survival

    Time frame: up to 1 year

    survival

  2. myocardial infarction size

    Time frame: within 72 hours of hospital admission

    mi size using peak elevation of cardiac biomarkers

  3. ECG infarct size

    Time frame: with 10 days or hospital discharge whichever occurs first

    QRS score on baseline and discharge ECGS

  4. Reperfusion

    Time frame: within 24 hours of admission to hospital

    ST segment resolution 30 minutes post PCI

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Collaborators

  • Canadian VIGOUR Centre

Registry information

Official study title

A Multi-center Randomized Trial of Remote Ischemic Conditioning to Reduce Infarct Size in Patients With an ST-Elevation Myocardial Infarction

Acronym: RemCon-STEMI

Important dates

Study start
2013
Primary completion
2017
Study completion
2018
First posted
Apr 29, 2019
Registry last updated
Apr 29, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.