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Active, Not Recruiting

NCT Number: NCT07292311

Reliability of Muscle Strength and Activation Assessment Tools and Effects of an Online Therapeutic Exercise Program in Patients With Chronic Kidney Disease

This research aims to evaluate the reliability and reproducibility of muscle strength and activation measurement tools, including isokinetic dynamometry and surface electromyography, in patients with chronic kidney disease (CKD). Additionally, the study will assess the feasibility and potential benefits of an online therapeutic exercise program supervised by physiotherapists.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Chronic Kidney Disease Atrophy Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Muscle Weakness Muscular Atrophy Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Physical Fitness Physical Therapy Modalities Renal Insufficiency Renal Insufficiency, Chronic Sarcopenia Signs and Symptoms Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Facultad de Enfermería y Terapia Ocupacional

Cáceres, 10003, Spain

About this study

Patients with chronic kidney disease experience progressive muscle weakness and reduced physical capacity due to systemic inflammation, metabolic acidosis, and inactivity.

This two-phase observational and interventional study, conducted in collaboration with the ALCER Association (Badajoz and Cáceres, Spain), will:

  • Determine the test-retest reliability of muscle assessment tools (isokinetic dynamometer, surface electromyography, and handheld dynamometry).
  • Implement and evaluate an online therapeutic exercise program supervised by physiotherapists.

The project aims to provide valid and reliable protocols for neuromuscular assessment in CKD patients and explore the feasibility of remote therapeutic exercise.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ≥18 years old.
  • Diagnosis of chronic kidney disease (hemodialysis, peritoneal dialysis, or kidney transplant).
  • Member of ALCER Association (Badajoz or Cáceres).
  • Medical clearance for physical testing/exercise.

Exclusion criteria

  • Severe cognitive or communication impairment.
  • Unstable cardiovascular or musculoskeletal conditions.
  • Refusal to provide informed consent.

Treatment and study plan

Reliability Assessment

Device

Device: Isokinetic dynamometer and mDurance® surface EMG Test-retest reliability of isokinetic and surface EMG measurements in upper limb, trunk, and lower limb

Online Therapeutic Exercise

Behavioral

Behavioral: Online therapeutic exercise program 8-10 week supervised online program including resistance and mobility exercises

Primary outcomes

  1. Test-retest reliability of surface EMG (Electromiography) activation.

    Time frame: 7-10 days

    RMS (root mean square). microvolts

  2. Test-retest reliability of isokinetic strength

    Time frame: 7-10 days

    Intraclass Correlation Coefficient - ICC. Strength (kilograms)

  3. Change in handgrip and limb strength measured by VALD dynamometry

    Time frame: Baseline and 12 weeks

    strength (kilograms)

Sponsors and collaborators

Lead sponsor

University of Extremadura

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 18, 2025
Registry last updated
Dec 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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