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NCT Number: NCT05784480

Relevance of Reversible Causes During OHCA (Rebecca Study)

Management of the reversible causes in cardiac arrest is fundamental for successful treatment of out-of-hospital cardiac arrests. Point-of-care diagnostics as prehospital emergency ultrasound, blood gas analysis and toxicological screening support the diagnostic process of evaluating potential reversible causes. Digital tools provide support of a structured approach. This study aims to evaluate the frequency of reversible causes during OHCA as well as specific interventions due to these findings. Furthermore, CPR performance (hands-off, ROSC, 30-day mortality) and cognitive load of the prehospital emergency physician will be investigated. In total 100 patients with OHCA will be included in this study. Identification of reversible causes will be performed upon a structured protocol using an interactive checklist. Cognitive load of emergency physician as well as CPR parameter (frequency of reversible causes, hands-off, ROSC, 30-day mortality) will be analysed.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Out-Of-Hospital Cardiac Arrest Cardiopulmonary Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Anesthesiology and Intensive Care Medicine Department - Medical University of Vienna, Vienna, Austria

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with prehospital cardiac arrest, where POCUS, blood gas analysis as well as screening for intoxication can integrated in ALS rhythm without delay of life-saving treatment or transportation will be included.

Exclusion criteria

  • Patients will be excluded under the age of 18, or if POCUS, blood gas analysis will lead to a delay of live-saving treatment or transportation. Furthermore, pregnant patients will be excluded.

Treatment and study plan

Checklist for evaluation of reversible causes

Diagnostic Test

Prehospital evaluation by checklist and diagnostic testing for reversible causes of OHCA using point-of-care blood gas analysis, saliva toxicological screen and ultrasound and post-hoc toxicological analysis of blood using mass spectrometry

Other names: Venipuncture for toxicological screening, Point-of-Care blood gas analysis, Point-of-Care saliva toxicological screen, Point-of-care ultrasound

Primary outcomes

  1. Frequency of reversible causes in OHCA and alterations of treatment

    Time frame: up to 30 days

    The primary outcome of this study evaluates the frequency of reversible causes during OHCA.

Secondary outcomes

  1. Frequency of ROSC

    Time frame: up to 30 days

    Any prehospital ROSC/sustained ROSC/in-hospital ROSC

  2. 30-day mortality

    Time frame: up to 30 days

    rate of mortality within 30 days in case of hospital admission

  3. Hands-off time

    Time frame: During study completion, up to 120 min

    Hands-off time during process of identification of reversible causes

  4. Cognitive load

    Time frame: 1 year (evaluation in documentation phase after CPR)

    NASA Task Load Index evaluated by the prehospital emergency physician after rescue mission

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Collaborators

  • Ludwig Boltzmann Institute for Digital Health and Prevention
  • Seibersdorf Labor GmbH

Registry information

Acronym: REBECCA

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Mar 27, 2023
Registry last updated
Apr 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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