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Completed

NCT Number: NCT05039502

Releasing of Inflammatory Mediators During Retreatment of Root Canals

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

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Key information

Conditions

Inflammatory Response Root Canal Infection

Age range

18 year–68 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry of Bulent Ecevit University

Zonguldak, Turkey (Türkiye)

About this study

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who had single root canal treated teeth with chronic periapical lesion

Exclusion criteria

  • Patients who are immunocompromised
  • Patients under antibiotic or analgesic medication

Treatment and study plan

Protaper Universal Retreatment

Other

D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor

Reciproc

Other

R25 retratment files were used with X-Smart endomotor in reciprocal motion

XP-Endo finisher R

Other

XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Primary outcomes

  1. change of inflammatory mediator level

    Time frame: 24 hours

    The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml.

Sponsors and collaborators

Lead sponsor

Bulent Ecevit University

Other

Registry information

Official study title

The Effect of Different File Systems Used in Retreatment on the Release of Inflammatory Mediators

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Sep 9, 2021
Registry last updated
Sep 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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