Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients

Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood. The Phosphatase and Tensin homolog (PTEN) is known to influence glucose homeostasis by interfering in intracellular insulin signaling.

Aim of this study is to ascertain whether differential expression of PTEN in critically ill patients correlates with glycemic variability and clinical outcome.

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Key information

Conditions

Critical Illness Disease Attributes Glucose Metabolism Disorders Hyperglycemia Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Rome La Sapienza, University Hospital

Rome, 00185, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

trauma
provision informed consent

Exclusion criteria

diabetes
impaired fasting glucose levels

Treatment and study plan

Primary outcomes

Length of ICU stay

Time frame: Day 1 up to day 28

Secondary outcomes

Glycemic variability as expressed by standard deviation of the glycemia measurements

Time frame: Day 1 up to day 28

Sponsors and collaborators

Lead sponsor

University of Roma La Sapienza

Other

Registry information

Official study title

Influence of PTEN on Glycemic Variability and Clinical Outcome in the Critically Ill Patient.

Acronym: GLUPTEN

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2015
First posted: Feb 22, 2013
Registry last updated: Nov 7, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed