Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases

On the basis of previous studies, a validation cohort will be established to explore the relationship between oral lichen planus and autoimmune thyroid diseases, and a disease efficacy prediction strategy can be formed.

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Key information

Conditions

Oral Lichen Planus Lichen Planus Lichen Planus, Oral Lichenoid Eruptions Mouth Diseases Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Stomatology Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310014, China

About this study

For oral lichen planus patients, the prevalence of Hashimoto's thyroiditis will be investigated and the relationship between levels of anti-TG, anti-TPO antibodies and severity of oral lichen planus will be determined.

Besides, for patients with Hashimoto's thyroiditis, the prevalence of oral lichen planus will be investigated and the relationship between levels of anti-TG, anti-TPO antibodies and severity of oral lichen planus will be determined.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

OLP patients without systemic disease

Exclusion criteria

OLP patients with severe periodontal disease

Treatment and study plan

No intervention

Other

Primary outcomes

Oral lichen planus (OLP) lesions record

Time frame: 1 year

Record changes of lesions based on the symptoms and signs of the oral lichen planus patient.
Level of thyroid function and antibody

Time frame: 1 year

The levels of thyroid hormone and thyroid autoantibodies in serum of OLP patients were detected.

Sponsors and collaborators

Lead sponsor

The Dental Hospital of Zhejiang University School of Medicine

Other

Registry information

Official study title

Clinical Value of the Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases

Important dates

Study start: 2022
Primary completion: 2024
Study completion: 2024
First posted: Jun 3, 2022
Registry last updated: Sep 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed