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Completed

NCT Number: NCT04014439

Relationship Between NLR and Prealbumin Levels With Diaphragm Thickness

A study to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.

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Key information

Conditions

Inflammatory Response

Age range

17 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Indonesia University

Jakarta Pusat, DKI Jakarta, 10430, Indonesia

About this study

Weaning from ventilator sometimes can be failed and it happened due to several factors. One of the causes was Ventilator Induced Diaphragm Dysfunction (VIDD). This VIDD process occurred due to thinning process of the diaphragm thickness or decreased diaphragm muscle mass. The whole process happened due to inflammatory reaction that usually appeared on patients in Intensive Care Unit (ICU). Thus, this study was aimed to find the relationship between neutrophil to lymphocyte ratio (NLR) with diaphragm thickness of critical patients in ICU.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Critical patients treated in intensive care unit using mechanical ventilation from day 0.
  • Patients are clinically predicted to be treated for more than 5 days (qSOFA and clinical assessment)

Exclusion criteria

  • History of suffering from neuromuscular disease and or diaphragmatic malformations
  • Used non-invasive ventilation before starting to use mechanical ventilation
  • History of tracheostomy
  • Patients admitted to ICU within 12 months before this study

Treatment and study plan

Ratio of Neutrophil to Lymphocyte

Diagnostic Test

Each patient was examined for a blood sample of 6 ml of venous blood taken from the cubital vein using a vacuum tube without anticoagulants. Blood samples were centrifuged at a speed of 3500 rpm for 20 minutes. Samples are processed with abbott® devices, to obtain neutrophil and serum lymphocyte levels. Plasma samples are stored in the refrigerator -20 C. The patient's diaphragm thickness was measured on days 0, 3, 5 and then the measurement was compared. Diaphragm thickness was measured in patients using mechanical ventilation in intensive care rooms.

Level of Prealbumin Serum

Diagnostic Test

Each patient was examined for a blood sample of 6 ml of venous blood taken from the cubital vein using a vacuum tube without anticoagulants. Blood samples were centrifuged at a speed of 3500 rpm for 20 minutes. Samples are processed with abbott® devices, to obtain neutrophil and serum lymphocyte levels. Plasma samples are stored in the refrigerator -20 C. The patient's diaphragm thickness was measured on days 0, 3, 5 and then the measurement was compared. Diaphragm thickness was measured in patients using mechanical ventilation in intensive care rooms.

Primary outcomes

  1. Level of Prealbumin Serum

    Time frame: 5 days

  2. Ratio of Neutrophil to Lymphocyte

    Time frame: 5 days

Sponsors and collaborators

Lead sponsor

Indonesia University

Other

Registry information

Official study title

Relationship Between Neutrophil to Lymphocyte Ratio and Prealbumin Serum Levels With Diaphragm Thickness in Critical Patients

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Jul 10, 2019
Registry last updated
Jan 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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