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Completed

NCT Number: NCT02617433

Relationship Between Muscle Mass and Muscle Relaxation Time

Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. The purpose of this study is to find relationship between muscle mass and muscle relaxation time.

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Key information

Conditions

Anesthesia

Age range

19 year–64 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Korea university anam hospital

Seoul, 02841, South Korea

About this study

Rocuronium block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. There have been several studies reported positive relationship between muscle mass and amount of neuromuscular junction. Until now, dose of rocuronium has been judged by patient's weight and height. However, height and weight do not represent exact muscle mass. The purpose of this study is to find relationship between muscle mass and muscle relaxation time. Measurement of muscle mass will be obtained using bioelectrical impedence analysis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patient who undergo general anesthesia.
  • Male; weight 70-75kg , height 170-175cm
  • Female; weight 53-58kg , height 158-163cm

Exclusion criteria

  • Liver and kidney disease
  • Any types of muscle disorder.
  • Metal materials or pacemaker in body

Treatment and study plan

Inbody

Device

Participant measure muscle mass by bioelectrical impedance analysis (Inbody 720, Seoul, Korea) after fast for eight hours. After measurement, patient is induced anesthesia. Rocuronium dose is 12mg for male, and 9mg for female.

Primary outcomes

  1. ratio of result of first stimulus(T1) to result of supramaximal stimulation(T0)

    Time frame: two hours

    T1 and T0 is obtained by train of four which is commonly used neuromuscular monitoring device.

Secondary outcomes

  1. completely suppression time of result of first stimulus(T1).

    Time frame: ten minutes

    T1 is obtained by train of four which is commonly used neuromuscular monitoring device.

Other outcomes

  1. Time until reoccurrence of response of first stimulus(T1).

    Time frame: two hours

    T1 is obtained by train of four which is commonly used neuromuscular monitoring device.

Sponsors and collaborators

Lead sponsor

Go Eun Bae

Other

Registry information

Official study title

Relationship Between Muscle Mass Measured by Bioelectrical Impedance Analysis and Muscle Relaxation

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Dec 1, 2015
Registry last updated
May 4, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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