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OpenTrials
Completed

NCT Number: NCT06891846

Relationship Between Magnesium Depletion Score and Extraction Socket Healing

The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH).

SH is a complex and highly regulated biological process. Several local, surgical, and systemic factors can influence SH. This study aimed to evaluate the impact of the magnesium depletion score (MDS) on the socket healing following tooth extraction.

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Key information

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sağlık Bilimleri Üniversitesi Tacirler Eğitim Vakfı Sultanbeyli Ağız ve Diş Sağlığı Hastanesi

Istanbul, Sultanbeyli, 34920, Turkey (Türkiye)

About this study

The surgical extraction of impacted teeth is one of the most commonly performed procedures in the field of oral surgery. According to the American Dental Association (ADA), surgical extraction involves "the removal of a tooth that has either erupted or not into the mouth, which includes the removal of a mucoperiosteal flap and the trimming of a portion of the tooth and/or bone." Complications related to post-extraction wound healing-such as pain, swelling, bleeding, and infection-can pose significant challenges for both patients and surgeons. Optimal healing depends not only on the tissue itself but also on various local, surgical, and systemic factors, including but not limited to the patient's stress levels, oral hygiene, age, sex, overall health status, and nutrition, many of which may be beyond intervention or control. Consequently, there is growing interest in treatments that can enhance wound healing. Recent studies indicate that magnesium consumption may have a beneficial effect on the healing process.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy adult participants who were scheduled to undergo surgical extraction of lower impacted third molars.

Exclusion criteria

  • Refusal to consent
  • Presence of chronic diseases
  • Use of medications that affect wound healing (steroids, bisphosphonate, or immunosuppressives)
  • Prior radiotherapy in the head and neck area
  • Pregnancy
  • Inability to self-evaluate, and inability to communicate verbally or in writing.

Treatment and study plan

Primary outcomes

  1. Magnesium depletion score (MDS)

    Time frame: 6 weeks

    The MDS is calculated by aggregating four factors:

    • Diuretic use: Current use of diuretics is assigned 1 point.
    • PPI use: Current use of proton pump inhibitors (PPIs) is assigned 1 point.
    • Kidney function:
    • If the estimated glomerular filtration rate (eGFR) is between 60 and 90 mL/(min · 1.73 m²), 1 point is assigned.
    • If the eGFR is less than 60 mL/(min · 1.73 m²), 2 points are assigned.

    The total MDS score ranges from 0 to 4, based on the accumulation of points from these factors.

  2. Assessment of Wound healing (WH)

    Time frame: 6 weeks

    Wound Healing (WH) will be assessed by using a scale called Inflammatory Proliferative Remodeling (IPR) Scale. According to the scale, each phase of WH is scored based on the parameters, including edema, bleeding and swelling.

    The total score of the IPR scale ranges from 0 to 16; 0-4 indicates poor healing; 5-10, acceptable healing; and 11-16, excellent healing.

Secondary outcomes

  1. Post-operative pain

    Time frame: 3 days

    Post-operative pain will be assessed using the Visual Analog Scale (VAS). Patients will be asked to rate their pain on a scale from 0 to 10, where 0 indicates no pain and 10 represents the worst imaginable pain.

Sponsors and collaborators

Lead sponsor

Saglik Bilimleri Universitesi

Other

Registry information

Official study title

Evaluation of the Relationship Between Magnesium Depletion Score And Socket Healing Following Tooth Extraction

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 24, 2025
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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