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OpenTrials
Completed

NCT Number: NCT04821492

Relationship Between Homocysteine and BMD

The association between Homocysteine (Hcy) levels and bone mineral density (BMD) has been debated. Some studies have found a relationship between increased Hcy plasma levels and BMD in contrast; other studies have not found a relationship. The purpose of our study was to investigate whether or not Hcy plasma levels are related to BMD in a group of postmenopausal women.

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Key information

Conditions

Postmenopausal Women

Age range

50 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Hospital Universitario Quiron Dexeus

Barcelona, 08028, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Postmenopausal women
  • BMD measured by dual-energy X-ray absorptiometry (DXA)

Exclusion criteria

  • Primary ovarian failure
  • Early menopause
  • Cardiovascular, liver, or renal diseases
  • Surgical menopause
  • History of cancer
  • Receiving treatment known to influence levels of Hcy or bone mineralization (folates or vitamin B12 supplements, menopausal hormonal treatment, corticosteroids, anticonvulsants, heparin, thiazide diuretics, and antiresorptive agents).

Treatment and study plan

Dual-Energy X-ray Absorptiometry (DXA)

Diagnostic Test

BMD expressed in absolute values as g/cm2 and T-scores

Primary outcomes

  1. BMD expressed in absolute values as g/cm2

    Time frame: one year before or after Homocysteine levels

  2. Lumbar spine T-score

    Time frame: one year before or after Homocysteine levels

  3. Femoral neck T-score

    Time frame: one year before or after Homocysteine levels

  4. Total hip T-score

    Time frame: one year before or after Homocysteine levels

Sponsors and collaborators

Lead sponsor

Fundación Santiago Dexeus Font

Other

Registry information

Official study title

Evaluation of the Relationship Between Homocysteine Levels and Bone Mineral Density in Postmenopausal Women

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Mar 29, 2021
Registry last updated
Sep 28, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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