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Completed

NCT Number: NCT03476668

Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.

The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).

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Key information

Conditions

Parkinson Disease Attention Disturbances Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this functioning, that is based on attention. Since the cognitive processes are related with dopamine, the asymmetrical degeneration of the dopaminergic system affects differently the right side affected (RPD) and the left side affected (LPD) PD patients.

The aim of the study was to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with PD.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Stage 2.5-3 according to the Hoehn and Yahr scale (H&Y);
  • Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;
  • Mini Mental State Examination (MMSE) ≥ 24;
  • No evidences of dysexecutive syndrome.

Exclusion criteria

  • Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;
  • Drug-induced dyskinesias;
  • Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;
  • Behavioral disturbances (evaluated with Neuropsychiatric Inventory);
  • Visual and auditory dysfunctions according to the general clinical evaluation and medical history;
  • Equivocal report about the side of disease onset or bilateral motor involvement.

Treatment and study plan

MIRT

Other

4-week multidisciplinary intensive rehabilitation treatment

Primary outcomes

  1. Visual Reaction Times (V RTs)

    Time frame: 4 weeks

    Visual Reaction Times

  2. Auditory Reaction Times (A RTs)

    Time frame: 4 weeks

    Auditory Reaction Times

  3. Multiple Choices RTs (MC RTs)

    Time frame: 4 weeks

    Multiple Choices RTs

Secondary outcomes

  1. Unified Parkinson's Disease Rating Scale (UPDRS)

    Time frame: 4 weeks

    Unified Parkinson's Disease Rating Scale

  2. Timed Up and Go Test (TUG)

    Time frame: 4 weeks

    Timed Up and Go Test

Sponsors and collaborators

Lead sponsor

Ospedale Generale Di Zona Moriggia-Pelascini

Other

Registry information

Acronym: RTsAsMIRT

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Mar 26, 2018
Registry last updated
May 30, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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