Istanbul Medeniyet University
Istanbul, 34722, Turkey (Türkiye)
NCT Number: NCT04158609
Term pregnancies within their 37-41 gestational week, who were planned to undergo induction of labor, were included in the study. Prior to initiation of the induction of labor, all included pregnant women underwent an assessment of Doppler flow indices, which included fetal umblical artery PI (pulsatility index) and fetal middle cerebral artery (MCA:Middle cerebral arter) PI. Cerebroplacental Ratio (CPR) was calculated by dividing MCA PI value to umbilical artery PI (MCA PI/UA PI=CPR).Included pregnant women were categorized as Group 1 and Group 2, which comprised of those with CPR value below 1.0 and above 1.0, respectively. Route of delivery and fetal complications, described as umbilical cord pH<7.20, APGAR score at 5 minutes <7, meconium aspiration syndrome, newborn intensive care unit admission, neonatal sepsis and neonatal death.
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Notify Me18 year–40 year
Female
Observational
Istanbul, 34722, Turkey (Türkiye)
Term pregnancies within their 37-41 gestational week, who were planned to undergo induction of labor, were included in the study. Prior to initiation of the induction of labor, all included pregnant women underwent an assessment of Doppler flow indices, which included fetal umblical artery PI (pulsatility index) and fetal middle cerebral artery (MCA:Middle cerebral arter) PI. Cerebroplacental Ratio (CPR) was calculated by dividing MCA PI value to umbilical artery PI (MCA PI/UA PI=CPR).Included pregnant women were categorized as Group 1 and Group 2, which comprised of those with CPR value below 1.0 and above 1.0, respectively. All women who were considered appropriate for induction of labor were performed an pelvic examination and their Bishop scores were calculated. Those with a Bishop score equal to or below 5 were included in the study. Vaginal misoprostol (prostoglandin E1, 25 mcg) and dinoproston (prostoglandin E2, 10 mg) were used for induction of labor. Repeat doses were implemented in case of insufficient cervical ripening. Oxytocin was not used at the initial stages of labour, while it was used at the latter stages when necessary.
Route of delivery and fetal complications, described as umbilical cord pH<7.20, APGAR score at 5 minutes <7, meconium aspiration syndrome, newborn intensive care unit admission, neonatal sepsis and neonatal death.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Doppler flow indices, UA-PI, MCA-PI and CPR values, assessment performed prior to induction of labor
Time frame: Within 1-3 minutes following delivery
Umbilical cord blood sampling just after the delivery of the newborn and pH measurement
Time frame: Postpartum 5 minutes
APGAR score determined by the pediatrician at postpartum 5 minutes
Time frame: Within postpartum two weeks
Meconium aspiration syndrome diagnosed by the pediatrician, either clinically or by thorax X-ray film.
Time frame: Within postpartum 1 month period
Newborn intensive care unit administration, due to a variety of conditions, which were established by pediatrician
Time frame: Within postpartum 1 month period
Neonatal sepsis diagnosed by the pediatrician
Time frame: Within postpartum 1 month period
Neonatal death
Time frame: At the time of delivery
Route of delivery, either vaginally or by cesarean section
Istanbul Medeniyet University
Other
Assessment of the Relationship Between Delivery Route, Umbilical Cord pH and Fetal Complications With Doppler Parameters Measured Prior to Induction of Labor at Term Pregnancies.
Acronym: Doppler
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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