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NCT Number: NCT03288662

Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

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Key information

Age range

21 year–71 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

  • Introduction: the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.
  • Materials and methods:

2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors

2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013 to 7/2017.

2.3. methods:

  • study in chest CT scan:
  • Measure the maximun diameter of the tumor
  • The contour: smooth contour or irregular contour
  • The shape: round, oval and plaque base on the ratio between long axis and short axis of the tumor
  • Some other characteristics: Degree of enhancement, Level of drug absorbed, Calcification, Invasion the local organs and Capsular destruction.
  • Histopathological study: based on the 2004 WHO classification:
  • Thymoma: type A, AB, B1, B2, B3
  • Thymic carcinoma
  • Data processing: use software Epi Info 2000.
  • Expectation of results
  • Relationship between the size and histopathological type of thymic epithelial tumors.
  • Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All of patient have a chest CT scan pre-operation and a result of thymic epithelial tumors postoperative histopathology

Exclusion criteria

  • Incomplete or loss the CT and postoperative histopathology

Treatment and study plan

CT and histopathological classification

Other

Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors. Base on the characteristics in Chest CT scan in each postoperative histopathology results.

Primary outcomes

  1. maximun diameter of the tumor

    Time frame: 1 month

    Measure the maximun diameter of the tumor in chest CT scan

Sponsors and collaborators

Lead sponsor

Military Hospital 103

Other

Collaborators

  • Nguyen Truong Giang

Registry information

Official study title

Evaluate the Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Important dates

Study start
2013
Primary completion
2017
Study completion
2017
First posted
Sep 20, 2017
Registry last updated
Sep 20, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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